| Pargyline-sensitive selective accumulation of a radiolabeled MPTP analog in the primate cerebral cortex and basal ganglia. | |
| | |
MedLine Citation:
|
PMID: 2111588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The distribution of radioiodinated N-methyl-4-(4-hydroxy-3-iodobenzyl)-1,2,3,6-tetrahydropyridine (MHTP), an analog of the reportedly nontoxic N-methyl-4-benzyl-1,2,3,6-tetrahydropyridine, (4-homo-MPTP), has been studied in the primate. [123I]MHTP-derived radioactivity exhibited a progressive accumulation and prolonged retention within the primate eye. Following iv injection, [123I]MHTP rapidly accumulated within the primate brain and was subsequently oxidized to a radiolabeled metabolite. The half-life of [123I]MHTP-derived radioactivity within the primate brain was 50 min. The highest concentrations of radioactivity were found in the caudate-putamen and the frontal, temporal and cingulate cortices; the substantia nigra and inferior olivary nucleus were labeled with medium intensity. Very low concentrations of radiolabel were detected in the cerebellum and white matter. Selective accumulation of [125I]MHTP-derived radioactivity within these structures was blocked by pretreatment with pargyline, suggesting that monoamine oxidase B is involved in the bioactivation of radioiodinated MHTP. |
| | |
Authors:
|
S M Efange; H F Kung; D C Mash; M Jabir; J Billings; J Pablo; A Dutta; A Freshler |
Related Documents
:
|
21968458 - Anesthetic-related neurotoxicity and the developing brain: shall we change practice? 21931668 - A corticothalamic circuit model for sound identification in complex scenes. 8305128 - The functional neuroanatomy of tourette's syndrome: an fdg-pet study. i. regional chang... 3612548 - Entrance of tetrahydropterin derivatives in brain after peripheral administration: effe... 18078708 - Square-wave jerks and smooth pursuit impairment as subtle early signs of brain involvem... 18957218 - Bhlhb5 regulates the postmitotic acquisition of area identities in layers ii-v of the d... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Synapse (New York, N.Y.) Volume: 5 ISSN: 0887-4476 ISO Abbreviation: Synapse Publication Date: 1990 |
Date Detail:
|
Created Date: 1990-06-25 Completed Date: 1990-06-25 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8806914 Medline TA: Synapse Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 207-12 Citation Subset: IM |
Affiliation:
|
Department of Radiology, University of Minnesota, Minneapolis. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
/
analogs & derivatives* Animals Autoradiography Basal Ganglia / drug effects, metabolism* Cerebral Cortex / drug effects, metabolism* Female Haplorhini / metabolism* Image Processing, Computer-Assisted Pargyline / pharmacology* Phosphothreonine / analogs & derivatives*, pharmacokinetics Threonine / analogs & derivatives* |
| Grant Support | |
ID/Acronym/Agency:
|
1R29NS26611/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
104302-77-4/7-mercaptoheptanoylthreonine phosphate; 1114-81-4/Phosphothreonine; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 555-57-7/Pargyline; 72-19-5/Threonine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Viscoelastic substances in ophthalmology.
Next Document: Insulin, cortisol and catecholamines do not regulate circadian variations in fibrinolytic activity.