Document Detail


Parenteral nutrition supplemented with glutamine in patients undergoing bone marrow transplantation.
MedLine Citation:
PMID:  20204255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MATERIAL AND METHODS: Retrospective observational study in 68 adult patients undergoing a bone marrow transplantation who required PN for mucositis. Of these patients, 40 were given PN with 2,063 +/- 294 kcal/day and 98.6 +/- 13.9 g of amino acids/day, supplemented with Lglutamine (13.5-27 g/day), and 28 were given isocaloric (1,966 +/- 307 kcal/day) and isonitrogenated (92 +/- 16.3 g of amino acids/day) PN with standard glutamine-free amino acid solution. Antibiotic consumption and duration of hospital stay were analysed. Of the total cohort, hepatic profile was studied at the beginning and on day 7 of PN in 50 patients without liver disease at the start of PN.
RESULTS: There were no differences between both groups with regard to total number and duration of antibiotics prescribed or hospital stay. Of the 50 patients without hepatic alterations at the beginning of PN, 2 patients in the control group and 5 in the glutamine group developed a hepatic profile compatible with liver disease secondary to PN. Comparing both groups, there were no differences in hepatic enzyme values.
CONCLUSIONS: Supplementation with PN glutamine does not improve the variables studied, but the actual clinical use of glutamine in this haematological treatment should be studied further and its potential advantages identified.
Authors:
Lucía Alonso Pérez; A Fernández Vázquez; M A Valero Zanuy; P Gomis Muñoz; M León Sanz; A Herreros de Tejada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrición hospitalaria     Volume:  25     ISSN:  0212-1611     ISO Abbreviation:  Nutr Hosp     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-03-05     Completed Date:  2010-05-26     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  9100365     Medline TA:  Nutr Hosp     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  49-52     Citation Subset:  IM    
Affiliation:
Pharmacy Service, Hospital Universitario 12 de Octubre, Madrid, Spain. luci8216@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / administration & dosage,  therapeutic use
Bone Marrow Transplantation / adverse effects,  physiology*
Female
Glutamine / administration & dosage,  therapeutic use*
Humans
Liver Diseases / epidemiology,  prevention & control
Longitudinal Studies
Male
Middle Aged
Mucositis / therapy
Parenteral Nutrition*
Retrospective Studies
Risk Reduction Behavior
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 56-85-9/Glutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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