Document Detail

Parenteral nutrition in ventilated patients with chronic obstructive pulmonary disease: long chain vs medium chain triglycerides.
MedLine Citation:
PMID:  17115015     Owner:  NLM     Status:  MEDLINE    
AIM: The aim of this study was to assess the usefulness of a lipid formulation containing a physical mixture of medium (MCT) and long chain triglycerides (LCT) compared with a long chain triglycerides emulsion in patients affected by chronic obstructive pulmonary disease with acute respiratory failure. METHODS: Twenty-four patients requiring mechanical ventilation were randomly selected in 2 groups and received total parenteral nutrition. Twelve patients received a MCT/LCT emulsion (50:50), the others used a 100% LCT emulsion. Nutritional status, metabolic rate, time of ventilatory support and weaning were evaluated. RESULTS: Both groups showed an improvement of all nutritional parameters evaluated; oxygen uptake, carbon dioxide output and respiratory gas exchange ratio were similar in both groups. The duration of mechanical ventilation was not significantly different; however, the time of weaning in the MCT/LCT group was significantly shorter. The longer weaning time in the LCT group patients could be related to vasoactive intermediates deriving from long chain fatty acids. The T-cell subsets, which were evaluated for both groups, showed a significant decrease of T helper-T suppressor ratio in the LCT group. CONCLUSION: MCT/LCT emulsion is an effective lipid supplementation and should be considered the therapy of choice in COPD patients; however, the relationship between lipid emulsions administered and length of weaning requires further investigations.
G Iovinelli; F Marinangeli; A Ciccone; A Ciccozzi; M Leonardis; A Paladini; G Varrassi
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Minerva anestesiologica     Volume:  73     ISSN:  0375-9393     ISO Abbreviation:  Minerva Anestesiol     Publication Date:    2007 Jan-Feb
Date Detail:
Created Date:  2007-03-14     Completed Date:  2007-05-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375272     Medline TA:  Minerva Anestesiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  65-76     Citation Subset:  IM    
Department of Anesthesiology, Intensive Care and Pain Management, University of L'Aquila, L'Aquila, Italy.
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MeSH Terms
Lymphocyte Count
Parenteral Nutrition*
Pulmonary Disease, Chronic Obstructive / drug therapy,  physiopathology,  therapy*
Respiration, Artificial*
Structure-Activity Relationship
T-Lymphocyte Subsets
Triglycerides / chemistry,  therapeutic use*
Reg. No./Substance:

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