| Parenteral nutrition in ventilated patients with chronic obstructive pulmonary disease: long chain vs medium chain triglycerides. | |
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MedLine Citation:
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PMID: 17115015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The aim of this study was to assess the usefulness of a lipid formulation containing a physical mixture of medium (MCT) and long chain triglycerides (LCT) compared with a long chain triglycerides emulsion in patients affected by chronic obstructive pulmonary disease with acute respiratory failure. METHODS: Twenty-four patients requiring mechanical ventilation were randomly selected in 2 groups and received total parenteral nutrition. Twelve patients received a MCT/LCT emulsion (50:50), the others used a 100% LCT emulsion. Nutritional status, metabolic rate, time of ventilatory support and weaning were evaluated. RESULTS: Both groups showed an improvement of all nutritional parameters evaluated; oxygen uptake, carbon dioxide output and respiratory gas exchange ratio were similar in both groups. The duration of mechanical ventilation was not significantly different; however, the time of weaning in the MCT/LCT group was significantly shorter. The longer weaning time in the LCT group patients could be related to vasoactive intermediates deriving from long chain fatty acids. The T-cell subsets, which were evaluated for both groups, showed a significant decrease of T helper-T suppressor ratio in the LCT group. CONCLUSION: MCT/LCT emulsion is an effective lipid supplementation and should be considered the therapy of choice in COPD patients; however, the relationship between lipid emulsions administered and length of weaning requires further investigations. |
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Authors:
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G Iovinelli; F Marinangeli; A Ciccone; A Ciccozzi; M Leonardis; A Paladini; G Varrassi |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Minerva anestesiologica Volume: 73 ISSN: 0375-9393 ISO Abbreviation: Minerva Anestesiol Publication Date: 2007 Jan-Feb |
Date Detail:
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Created Date: 2007-03-14 Completed Date: 2007-05-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375272 Medline TA: Minerva Anestesiol Country: Italy |
Other Details:
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Languages: eng Pagination: 65-76 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Intensive Care and Pain Management, University of L'Aquila, L'Aquila, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Female Humans Lymphocyte Count Male Parenteral Nutrition* Pulmonary Disease, Chronic Obstructive / drug therapy, physiopathology, therapy* Respiration, Artificial* Structure-Activity Relationship T-Lymphocyte Subsets Triglycerides / chemistry, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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