| Parenteral insulin suppresses T cell proliferation to islet antigens. | |
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MedLine Citation:
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PMID: 20522167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The diabetes prevention trial-type 1 (DPT-1) tested whether a combination of SQ and IV insulin therapy would delay the onset of disease in individuals at high risk of progression. We investigated whether this regimen altered T cell responses to human islet proteins using cellular immunoblotting. Among the 10 treated and 7 control subjects studied, we found that there was a significant effect of treatment on cellular immunoblotting responses. We conclude that parenteral insulin may suppress proliferation to islet antigens in individuals at risk for diabetes, but this effect may be transient. Further study is needed to determine whether a therapy that results in sustained suppression of T cell proliferation could yield a measurable clinical benefit. |
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Authors:
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Carla J Greenbaum; Marli McCulloch-Olson; Harvey K Chiu; Jerry P Palmer; Barbara Brooks-Worrell |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Pediatric diabetes Volume: 12 ISSN: 1399-5448 ISO Abbreviation: Pediatr Diabetes Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-26 Completed Date: 2011-08-18 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 100939345 Medline TA: Pediatr Diabetes Country: Denmark |
Other Details:
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Languages: eng Pagination: 150-5 Citation Subset: IM |
Copyright Information:
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© 2010 John Wiley & Sons A/S. |
Affiliation:
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Benaroya Research Institute, Seattle, WA, USA. cjgreen@benaroyaresearch.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Autoantibodies / blood, immunology Cell Division / drug effects, immunology Child Diabetes Mellitus, Type 1 / drug therapy*, epidemiology, prevention & control* Disease Progression Humans Hypoglycemic Agents / administration & dosage*, immunology Injections, Intravenous Injections, Subcutaneous Insulin / administration & dosage*, immunology Islets of Langerhans / immunology Parents Risk Factors T-Lymphocytes / cytology, drug effects*, immunology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR-00037/RR/NCRR NIH HHS; P30 DK017047-33S3/DK/NIDDK NIH HHS; P30 DK17047/DK/NIDDK NIH HHS; U01 DK046601-07/DK/NIDDK NIH HHS; U01 DK46601/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Hypoglycemic Agents; 0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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