| Parenteral fish oil monotherapy in the management of patients with parenteral nutrition-associated liver disease. | |
| | |
MedLine Citation:
|
PMID: 20566974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To update knowledge on the management of parenteral nutrition-associated liver disease (PNALD) and to review the clinical data on the use of parenteral fish oil for reversal of PNALD. DATA SOURCES: A literature review was conducted by searching the MEDLINE database (May 1, 2009) using the keywords parenteral nutrition-associated liver disease, fish oil, omega-3, Omegaven, and lipid emulsion. STUDY SELECTION: All articles reporting clinical cases with the use of parenteral fish oil for management of PNALD. DATA EXTRACTION: Three reviewers independently analyzed the epidemiological, clinical, and treatment data of the articles. DATA SYNTHESIS: Six case reports (10 patients) and 2 cohort studies (12 and 18 patients) were analyzed. CONCLUSIONS: Fish oil-derived emulsions have been demonstrated to reverse preexisting PNALD and to prevent and treat essential fatty acid deficiency. Its ability to prevent PNALD is currently under investigation. Although the mechanism has yet to be fully understood, the advantages of fish oil-based lipid emulsions over soybean oil-based lipid emulsions seen to date suggest that fish oil-based emulsions would be better suited for use in long-term parenteral nutrition. |
| | |
Authors:
|
Vincent E de Meijer; Kathleen M Gura; Jonathan A Meisel; Hau D Le; Mark Puder |
Related Documents
:
|
1909014 - Retropharyngeal space infection: changing trends. 20357944 - Mortality and morbidity associated with gunshot in raptorial birds from the province of... 19702594 - The burden of copd in africa: a literature review and prospective survey of the availab... 11339884 - American cutaneous leishmaniasis in guyana, south america. 6986734 - Cytologic monitoring of cerebrospinal fluid in the treatment of histiocytic lymphoma in... 16275404 - Locations of congenital cholesteatoma in the middle ear in japanese patients. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Archives of surgery (Chicago, Ill. : 1960) Volume: 145 ISSN: 1538-3644 ISO Abbreviation: Arch Surg Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-22 Completed Date: 2010-07-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9716528 Medline TA: Arch Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 547-51 Citation Subset: AIM; IM |
Affiliation:
|
Vascular Biology Program, Department of Surgery, Children's Hospital Boston, Harvard Medical School, 300 Longwood Ave, Fegan 3, Boston, MA 02115, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Disease Models, Animal Fat Emulsions, Intravenous / adverse effects, therapeutic use Fatty Acids, Omega-3 / adverse effects, therapeutic use Female Fish Oils / administration & dosage* Follow-Up Studies Humans Liver Diseases / etiology*, therapy* Liver Function Tests Male Mice Parenteral Nutrition / adverse effects*, methods Randomized Controlled Trials as Topic Risk Assessment Severity of Illness Index Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
|
DK069621-03/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fat Emulsions, Intravenous; 0/Fatty Acids, Omega-3; 0/Fish Oils |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The 3 essential responsibilities: a leadership story.
Next Document: Five-year follow-up of a multicenter, double-blind randomized clinical trial of laparoscopic Nissen ...