Document Detail

Parenteral fish oil monotherapy in the management of patients with parenteral nutrition-associated liver disease.
MedLine Citation:
PMID:  20566974     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To update knowledge on the management of parenteral nutrition-associated liver disease (PNALD) and to review the clinical data on the use of parenteral fish oil for reversal of PNALD. DATA SOURCES: A literature review was conducted by searching the MEDLINE database (May 1, 2009) using the keywords parenteral nutrition-associated liver disease, fish oil, omega-3, Omegaven, and lipid emulsion. STUDY SELECTION: All articles reporting clinical cases with the use of parenteral fish oil for management of PNALD. DATA EXTRACTION: Three reviewers independently analyzed the epidemiological, clinical, and treatment data of the articles. DATA SYNTHESIS: Six case reports (10 patients) and 2 cohort studies (12 and 18 patients) were analyzed. CONCLUSIONS: Fish oil-derived emulsions have been demonstrated to reverse preexisting PNALD and to prevent and treat essential fatty acid deficiency. Its ability to prevent PNALD is currently under investigation. Although the mechanism has yet to be fully understood, the advantages of fish oil-based lipid emulsions over soybean oil-based lipid emulsions seen to date suggest that fish oil-based emulsions would be better suited for use in long-term parenteral nutrition.
Vincent E de Meijer; Kathleen M Gura; Jonathan A Meisel; Hau D Le; Mark Puder
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  145     ISSN:  1538-3644     ISO Abbreviation:  Arch Surg     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  547-51     Citation Subset:  AIM; IM    
Vascular Biology Program, Department of Surgery, Children's Hospital Boston, Harvard Medical School, 300 Longwood Ave, Fegan 3, Boston, MA 02115, USA.
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MeSH Terms
Disease Models, Animal
Fat Emulsions, Intravenous / adverse effects,  therapeutic use
Fatty Acids, Omega-3 / adverse effects,  therapeutic use
Fish Oils / administration & dosage*
Follow-Up Studies
Liver Diseases / etiology*,  therapy*
Liver Function Tests
Parenteral Nutrition / adverse effects*,  methods
Randomized Controlled Trials as Topic
Risk Assessment
Severity of Illness Index
Treatment Outcome
Grant Support
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Fatty Acids, Omega-3; 0/Fish Oils

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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