| Parenteral feeding alters the fatty acid composition of serum phospholipids of rabbits. | |
| | |
MedLine Citation:
|
PMID: 9527967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Cholestatic liver disease develops in 30% to 70% of neonates receiving total parental nutrition (TPN). We analyzed the fatty acid composition of serum phospholipids from control and TPN-fed rabbits to determine if TPN altered the fatty acid profile. METHODS: Eleven male New Zealand White rabbits aged 9 to 11 weeks received TPN, whereas 11 other rabbits were offered standard laboratory rabbit chow ad libitum. After 14 days on the prescribed diet, serum samples were analyzed for their phospholipid fatty acid content by gas chromatography. RESULTS: The proportions of palmitolenic (16:2n7), alpha-linolenic (18:3n3), arachidic (20:0), and eicosaenoic (20:1n9) acids were significantly lower in the serum phospholipids of the TPN-fed animals compared with the control group. The proportion of docosahexaenoic acid (22:6n3), a fatty acid that is critical to the development of the nervous system, was increased two- to threefold. CONCLUSIONS: The differences in proportions of fatty acids observed between control and TPN-fed animals indicate that a fatty acid elongation and desaturation pathways are perturbed in rabbits on TPN. |
| | |
Authors:
|
R L Moss; T M Enomoto; A Haynes; D E Fry; R H Glew |
Related Documents
:
|
2687587 - Phospholipid flip-out controls the cell cycle of escherichia coli. 2210237 - Phospholipids from rat, human, and canine gastric mucosa. composition and metabolism of... 9227357 - Effects of dietary supplementation with alpha-linolenic acid on the phospholipid fatty ... 3145987 - Alternative lipids to usual omega 6 pufas: gamma-linolenic acid, alpha-linolenic acid, ... 18004737 - Binding study of flos lonicerae japonicae with bovine serum albumin using centrifugal u... 22009657 - The front-end desaturase: structure, function, evolution and biotechnological use. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: JPEN. Journal of parenteral and enteral nutrition Volume: 22 ISSN: 0148-6071 ISO Abbreviation: JPEN J Parenter Enteral Nutr Publication Date: 1998 Mar-Apr |
Date Detail:
|
Created Date: 1998-05-12 Completed Date: 1998-05-12 Revised Date: 2007-02-21 |
Medline Journal Info:
|
Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 98-101 Citation Subset: IM |
Affiliation:
|
Department of Surgery, Stanford University School of Medicine, Palo Alto, California, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acids
/
administration & dosage* Animal Feed / analysis Animals Cholestasis / etiology Cohort Studies Fat Emulsions, Intravenous / administration & dosage Fatty Acids / analysis, blood*, classification Fatty Acids, Omega-3 / blood Fatty Acids, Omega-6 Fatty Acids, Unsaturated / blood Food, Formulated* / adverse effects, analysis Male Palmitic Acids / blood Parenteral Nutrition, Total / adverse effects, methods* Phospholipids / blood*, chemistry Rabbits |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids; 0/Fat Emulsions, Intravenous; 0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated; 0/Palmitic Acids; 0/Phospholipids; 65072-01-7/Travasol |
| Comments/Corrections | |
Comment In:
|
JPEN J Parenter Enteral Nutr. 1998 Nov-Dec;22(6):401-2
[PMID:
9829616
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neither intact nor hydrolyzed soy proteins elicit intestinal inflammation in neonatal piglets.
Next Document: Electrolyte abnormalities in patients with chronic renal failure receiving parenteral nutrition.