Document Detail

Parenteral feeding alters the fatty acid composition of serum phospholipids of rabbits.
MedLine Citation:
PMID:  9527967     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cholestatic liver disease develops in 30% to 70% of neonates receiving total parental nutrition (TPN). We analyzed the fatty acid composition of serum phospholipids from control and TPN-fed rabbits to determine if TPN altered the fatty acid profile. METHODS: Eleven male New Zealand White rabbits aged 9 to 11 weeks received TPN, whereas 11 other rabbits were offered standard laboratory rabbit chow ad libitum. After 14 days on the prescribed diet, serum samples were analyzed for their phospholipid fatty acid content by gas chromatography. RESULTS: The proportions of palmitolenic (16:2n7), alpha-linolenic (18:3n3), arachidic (20:0), and eicosaenoic (20:1n9) acids were significantly lower in the serum phospholipids of the TPN-fed animals compared with the control group. The proportion of docosahexaenoic acid (22:6n3), a fatty acid that is critical to the development of the nervous system, was increased two- to threefold. CONCLUSIONS: The differences in proportions of fatty acids observed between control and TPN-fed animals indicate that a fatty acid elongation and desaturation pathways are perturbed in rabbits on TPN.
R L Moss; T M Enomoto; A Haynes; D E Fry; R H Glew
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  22     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    1998 Mar-Apr
Date Detail:
Created Date:  1998-05-12     Completed Date:  1998-05-12     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  98-101     Citation Subset:  IM    
Department of Surgery, Stanford University School of Medicine, Palo Alto, California, USA.
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MeSH Terms
Amino Acids / administration & dosage*
Animal Feed / analysis
Cholestasis / etiology
Cohort Studies
Fat Emulsions, Intravenous / administration & dosage
Fatty Acids / analysis,  blood*,  classification
Fatty Acids, Omega-3 / blood
Fatty Acids, Omega-6
Fatty Acids, Unsaturated / blood
Food, Formulated* / adverse effects,  analysis
Palmitic Acids / blood
Parenteral Nutrition, Total / adverse effects,  methods*
Phospholipids / blood*,  chemistry
Reg. No./Substance:
0/Amino Acids; 0/Fat Emulsions, Intravenous; 0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated; 0/Palmitic Acids; 0/Phospholipids; 65072-01-7/Travasol
Comment In:
JPEN J Parenter Enteral Nutr. 1998 Nov-Dec;22(6):401-2   [PMID:  9829616 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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