| Parenteral and enteral feeding in preterm piglets differently affects extracellular matrix proteins, enterocyte proliferation and apoptosis in the small intestine. | |
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MedLine Citation:
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PMID: 20887647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The preterm intestine is immature and responds differently to total parenteral nutrition (TPN) and enteral nutrition, compared with the term intestine. We hypothesised that in preterms, diet composition and feeding route affect mucosal morphology, enterocyte mitosis and apoptosis, and the distribution of laminin-1, fibronectin and collagen IV (extracellular matrix proteins (ECMP)). Preterm piglets (93.5 % of gestation) were delivered via caesarean section and birth weight-matched allocated to one of the four experimental groups: the piglets were either euthanised immediately after delivery, after 3 d of TPN or after 2 d enteral feeding with colostrum or milk formula, following 3 d of TPN. We combined immunohistochemistry, image analysis and stereological measurements to describe the intestinal mucosal layer. No significant changes occurred after 3 d of TPN. Feeding colostrum or milk replacer for 2 d after TPN was associated with an increased crypt depth. Only enteral feeding with colostrum resulted in an increased villus height and mitotic index. Neither TPN nor enteral feeding changed the distribution pattern of ECMP or the occurrence of bifid crypts. The immature distribution pattern of ECMP in TPN-fed piglets, coupled with unchanged enterocyte mitosis and apoptosis indices, illustrates that feeding preterm pigs 3 d TPN does not lead to mucosal atrophy. Despite the invariable distribution of ECMP, colostrum was associated with crypt hyperplasia resulting in an increased villus height. These data illustrate that some mechanisms regulating cell turnover are immature in preterms and may in part explain the abnormal gut responses to TPN and enteral feeding in prematurely born pigs. |
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Authors:
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Marijke Oste; Maartje De Vos; Els Van Haver; Leen Van Brantegem; Thomas Thymann; Per Sangild; Andre Weyns; Chris Van Ginneken |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of nutrition Volume: 104 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 989-97 Citation Subset: IM |
Affiliation:
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Laboratory of Veterinary Anatomy and Embryology, Department of Veterinary Medicine, University of Antwerp, 2610 Wilrijk, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Nutritional Physiological Phenomena Animals Animals, Newborn Apoptosis Cell Proliferation Colostrum Enteral Nutrition* Enterocytes / metabolism*, pathology Extracellular Matrix Proteins / metabolism* Food, Formulated Hyperplasia Intestinal Mucosa / growth & development* Intestine, Small / growth & development* Mitosis Parenteral Nutrition, Total* Swine |
| Chemical | |
Reg. No./Substance:
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0/Extracellular Matrix Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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