| Parenteral ascorbic acid in haemodialysis patients. | |
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MedLine Citation:
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PMID: 18827578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Parenteral ascorbic acid has been frequently used to overcome problems of vitamin C deficiency in haemodialysis patients. The benefits of vitamin C supplementation in clinical studies have been controversial and did not consider toxicological aspects. The review summarizes recent findings of the effects of parenteral ascorbic acid and discusses toxicological effects. RECENT FINDINGS: Vitamin C deficiency in haemodialysis patients, which has been frequently described, cannot be improved with oral supplementation due to limited absorption of high dosages. To avoid consequences of vitamin C deficiency, parenteral vitamin C solutions should be administered because this intervention is the only way to guarantee a sufficient supply to the cells. A beneficial consequence of parenteral vitamin C on the recombinant human erythropoietin resistance is an additional therapeutic effect, which contributes to the prevention of iron deficiency anaemia in haemodialysis patients. Thus, large amount of supplemental vitamin C are required for extended periods of time (up to 500 mg 3 times a week). To avoid hyperoxaluria, plasma oxalate levels should be monitored on a regular basis, for example, once a week. SUMMARY: Parenteral administration of ascorbic acid may be an approach that can overcome problems of vitamin C deficiency in haemodialysis patients - in particular problems of iron overload, erythropoetin resistance, and chronic inflammation. |
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Authors:
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Hans K Biesalski |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in clinical nutrition and metabolic care Volume: 11 ISSN: 1363-1950 ISO Abbreviation: Curr Opin Clin Nutr Metab Care Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-01 Completed Date: 2009-01-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9804399 Medline TA: Curr Opin Clin Nutr Metab Care Country: England |
Other Details:
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Languages: eng Pagination: 741-6 Citation Subset: IM |
Affiliation:
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Department of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany. biesal@uni-hohenheim.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Ascorbic Acid
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therapeutic use*,
toxicity* Ascorbic Acid Deficiency / drug therapy* Drug Resistance Erythropoietin / therapeutic use Hemosiderosis / drug therapy Humans Inflammation / drug therapy Infusions, Parenteral Renal Dialysis* / adverse effects |
| Chemical | |
Reg. No./Substance:
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11096-26-7/Erythropoietin; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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