Document Detail


Parenteral bisphosphonates for osteoporosis in patients with primary biliary cirrhosis.
MedLine Citation:
PMID:  20460985     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We aimed to describe the effects of parenteral bisphosphonates on bone mineral density (BMD) changes in primary biliary cirrhosis (PBC) patients with osteoporosis. Seventeen PBC patients with osteoporosis diagnosed between 1996 and 2005 were enrolled retrospectively. All patients received one of the following parenteral bisphosphonates: zoledronic acid, pamidronate disodium, or ibandronate sodium. The median (interquartile range) age of patients at osteoporosis diagnosis was 62.2 (56.4-67.9) and 94% were women. After treatment, percent change of lumbar spine bone mineral density (LS-BMD) and proximal femur BMD (PF-BMD) of patients with PBC was 2.9% and 0.4%, respectively. Eight patients (47%) showed a greater LS-BMD and/or PF-BMD with percent change of LS-BMD and PF-BMD of 8.7% and 0.8%, respectively. No serious adverse events were found. In PBC patients with osteoporosis, parenteral bisphosphonates can stabilize BMD for 47% of patients. More prospective studies are needed to evaluate the efficacy of specific parenteral bisphosphonates in patients with PBC and osteoporosis.
Authors:
Sombat Treeprasertsuk; Marina G Silveira; Janice L Petz; Keith D Lindor
Related Documents :
8025295 - Metacarpophalangeal pattern profile analysis in 14 japanese children with sotos syndrome.
7068355 - Is secondary hyperparathyroidism an important etiologic factor in the anemia of chronic...
21465315 - Evaluation of functional ability of rheumatoid arthritis based on haq score and bmd amo...
9474395 - The prognostic value of quantitative bone scan in knee osteochondritis dissecans. a pre...
18048855 - Prevalence and clinicoepidemiological features of moyamoya disease in japan: findings f...
9431865 - Idiopathic monomorphic ventricular tachycardia: clinical outcome, electrophysiologic ch...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of therapeutics     Volume:  18     ISSN:  1536-3686     ISO Abbreviation:  Am J Ther     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441347     Medline TA:  Am J Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  375-81     Citation Subset:  IM    
Affiliation:
1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN; and 2Division of Gastroenterology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hand-foot hyperpigmentation skin lesions associated with combination gemcitabine-carboplatin (GemCar...
Next Document:  Newer anticoagulants as an alternate to warfarin in atrial fibrillation: a changing paradigm.