Document Detail

Parental smoking and airway reactivity in healthy infants.
MedLine Citation:
PMID:  15502114     Owner:  NLM     Status:  MEDLINE    
Parental tobacco smoking is associated with lower airway function and an increased incidence of wheezy respiratory illnesses in infants. We evaluated in 76 healthy infants whether exposure to parental tobacco smoking was associated with airway hyperreactivity, which could contribute to lower airway function and the increased wheezy illnesses. Airway function was measured using the raised-volume rapid thoracic compression technique, and airway reactivity was assessed by methacholine challenge (0.015-10 mg/ml), which was stopped for a more than 30% decrease in forced expiratory flow (FEF)(75) or the final dose with a less than 30% decrease. Parental tobacco smoking was associated with lower baseline airway function (FEF(50), 600 vs. 676 ml/second, p < 0.04; FEF(25-75), 531 vs. 597 ml/second, p < 0.05). Infants exposed to tobacco smoking were approximately half as likely to develop a more than 30% decline in FEF(75) at any given methacholine dose (hazard ratio = 0.4, p = 0.001). In addition, a history of asthma in an extended family member increased the likelihood that an infant would develop a more than 30% decline in FEF(75) (hazard ratio = 1.7, p = 0.04). We conclude that exposure to parental smoking is associated with lower airway function but not increased airway reactivity; however, family history of asthma is associated with heightened airway reactivity.
Robert S Tepper; Tamica Williams-Nkomo; Tanya Martinez; Jeff Kisling; Cathy Coates; Joanne Daggy
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Publication Detail:
Type:  Journal Article     Date:  2004-10-22
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  171     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-23     Completed Date:  2005-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  78-82     Citation Subset:  AIM; IM    
Department of Pediatrics, Indiana University Medical Center, James Whitcomb Riley Hospital for Children, 702 Barnhill Drive, ROC 4270, Indianapolis, IN 46202-5225, USA.
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MeSH Terms
Bronchial Hyperreactivity / etiology*,  physiopathology
Bronchial Provocation Tests
Child, Preschool
Cotinine / analysis
Hair / chemistry
Maximal Midexpiratory Flow Rate
Methacholine Chloride / diagnostic use
Respiratory Sounds
Tobacco Smoke Pollution / adverse effects*
Reg. No./Substance:
0/Tobacco Smoke Pollution; 486-56-6/Cotinine; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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