| Parental smoking, CYP1A1 genetic polymorphisms and childhood leukemia (Québec, Canada). | |
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MedLine Citation:
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PMID: 10880037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effect of parental smoking on childhood acute lymphoblastic leukemia and to determine if it is modified by child genetic polymorphisms. METHODS: We carried out a case-control study in Quebec, Canada, including 491 incident cases aged 0-9 years and as many healthy controls matched on age and sex. Each parent was interviewed separately with respect to smoking habits during and after pregnancy. In addition, we carried out a case-only substudy with 158 cases classified according to presence or absence of the alleles *2A, *2B, and *4 in the CYP1A1 gene. RESULTS: There were small risk increases with maternal smoking during the later trimesters. Interaction odds ratios were increased (although often not significantly) for the CYP1A1*4 allele at high levels of maternal smoking in the last trimesters and at low level of paternal postnatal smoking, and decreased for the CYP1A1*2B allele. The latter appeared to confer a protective advantage at low levels for maternal prenatal smoking and at high levels for paternal postnatal smoking. CONCLUSIONS: Reported smoking habits showed no association with leukemia; risks for genetic polymorphisms lacked precision but indicated that the effect of parental smoking could be modified by variant alleles in the CYP1A1 gene. |
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Authors:
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C Infante-Rivard; M Krajinovic; D Labuda; D Sinnett |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer causes & control : CCC Volume: 11 ISSN: 0957-5243 ISO Abbreviation: Cancer Causes Control Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-10-12 Completed Date: 2000-10-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100846 Medline TA: Cancer Causes Control Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 547-53 Citation Subset: IM |
Affiliation:
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Joint Department of Epidemiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. cirivard@epid.lan.mcgill.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Case-Control Studies Child Child, Preschool Cytochrome P-450 CYP1A1 / genetics* Fathers Female Genetic Predisposition to Disease Humans Infant Logistic Models Male Odds Ratio Polymorphism, Genetic Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology, etiology*, genetics* Pregnancy Prenatal Exposure Delayed Effects Quebec / epidemiology Questionnaires Smoking* / epidemiology Tobacco Smoke Pollution / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Tobacco Smoke Pollution; EC 1.14.14.1/Cytochrome P-450 CYP1A1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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