Document Detail

Parental origin-dependent, male offspring-specific transmission-ratio distortion at loci on the human X chromosome.
MedLine Citation:
PMID:  9585588     Owner:  NLM     Status:  MEDLINE    
We have analyzed the transmission of maternal alleles at loci spanning the length of the X chromosome in 47 normal, genetic disease-free families. We found a significant deviation from the expected Mendelian 1:1 ratio of grandpaternal:grandmaternal alleles at loci in Xp11.4-p21.1. The distortion in inheritance ratio was found only among male offspring and was manifested as a strong bias in favor of the inheritance of the alleles of the maternal grandfather. We found no evidence for significant heterogeneity among the families, which implies that the major determinant involved in the generation of the non-Mendelian ratio is epigenetic. Our analysis of recombinant chromosomes inherited by male offspring indicates that an 11.6-cM interval on the short arm of the X chromosome, bounded by DXS538 and DXS7, contains an imprinted gene that affects the survival of male embryos.
A K Naumova; M Leppert; D F Barker; K Morgan; C Sapienza
Related Documents :
18156438 - The genetic aetiology of silver-russell syndrome.
21347268 - Differential expression of non-coding rnas and continuous evolution of the x chromosome...
9524578 - Genomic imprinting in testicular germ cell tumours.
20148908 - Influence of parental origin of the x chromosome on physical phenotypes and gh responsi...
11346798 - The ph1 locus is needed to ensure specific somatic and meiotic centromere association.
16088398 - Molecular mapping of k2 mdh1-n y20, an unstable chromosomal region in soybean [glycine ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of human genetics     Volume:  62     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-06-24     Completed Date:  1998-06-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1493-9     Citation Subset:  IM    
Fels Institute for Cancer Research, Temple University School of Medicine, Philadelpha, PA 19140, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Genomic Imprinting
Recombination, Genetic
X Chromosome*
Grant Support
Comment In:
Am J Hum Genet. 2000 Jan;66(1):330-2   [PMID:  10631163 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Haplotype mapping of a major quantitative-trait locus for fetal hemoglobin production, on chromosome...
Next Document:  A global haplotype analysis of the myotonic dystrophy locus: implications for the evolution of moder...