Document Detail


Parental origin-dependent, male offspring-specific transmission-ratio distortion at loci on the human X chromosome.
MedLine Citation:
PMID:  9585588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have analyzed the transmission of maternal alleles at loci spanning the length of the X chromosome in 47 normal, genetic disease-free families. We found a significant deviation from the expected Mendelian 1:1 ratio of grandpaternal:grandmaternal alleles at loci in Xp11.4-p21.1. The distortion in inheritance ratio was found only among male offspring and was manifested as a strong bias in favor of the inheritance of the alleles of the maternal grandfather. We found no evidence for significant heterogeneity among the families, which implies that the major determinant involved in the generation of the non-Mendelian ratio is epigenetic. Our analysis of recombinant chromosomes inherited by male offspring indicates that an 11.6-cM interval on the short arm of the X chromosome, bounded by DXS538 and DXS7, contains an imprinted gene that affects the survival of male embryos.
Authors:
A K Naumova; M Leppert; D F Barker; K Morgan; C Sapienza
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of human genetics     Volume:  62     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-06-24     Completed Date:  1998-06-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1493-9     Citation Subset:  IM    
Affiliation:
Fels Institute for Cancer Research, Temple University School of Medicine, Philadelpha, PA 19140, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Genomic Imprinting
Humans
Male
Mice
Recombination, Genetic
X Chromosome*
Grant Support
ID/Acronym/Agency:
DK43671/DK/NIDDK NIH HHS; R01 GM52332/GM/NIGMS NIH HHS
Comments/Corrections
Comment In:
Am J Hum Genet. 2000 Jan;66(1):330-2   [PMID:  10631163 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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