Document Detail


Parental lead exposure and total anomalous pulmonary venous return.
MedLine Citation:
PMID:  15108245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Investigators from the Baltimore-Washington Infant Study (BWIS) reported an association between self-reported maternal lead exposure and total anomalous pulmonary venous return (TAPVR) in their offspring. This association was further evaluated in the BWIS population using a more sensitive exposure estimate. METHODS: Cases included 54 live-born infants with TAPVR; controls were a stratified random sample of 522 live-born infants from the BWIS control group. Parental lead exposure was based on three assessment methods, including: an industrial hygiene assessment, an a priori job exposure matrix, and self-reported exposures. A parent was classified as exposed to lead if he/she was classified as exposed by any one of the assessment methods. RESULTS: Approximately 17% of case mothers and 11% of control mothers were classified as exposed to lead during the three months prior to conception through the first trimester (odds ratio [OR], 1.57; 95% confidence interval [CI], 0.64-3.47). Among fathers, 61% of case fathers and 46% of control fathers were classified as exposed to lead during the six months prior to conception (paternal critical period) (OR, 1.83; 95% CI, 1.00-3.42). During the paternal critical period, when only the father was exposed compared to neither parent exposed, the OR for any lead exposure and TAPVR was 1.65 (95% CI, 0.84-3.25). CONCLUSIONS: This study supports a possible association between paternal lead exposure and TAPVR. Further studies are warranted using validated assessment methods for occupational and nonoccupational lead exposures to corroborate this association and to elucidate the possible biological mechanism. Birth Defects Research (Part A), 2004.
Authors:
Leila W Jackson; Adolfo Correa-Villaseñor; Peter S J Lees; Francesca Dominici; Patricia A Stewart; Patrick N Breysse; Genevieve Matanoski
Related Documents :
21281885 - Prevalence of and risk factors for methicillin-resistant staphylococcus aureus coloniza...
14696855 - Preterm delivery and calculation of survival rate below 28 weeks of gestation.
7503205 - Recent changes in delivery site of low-birth-weight infants in washington: impact on bi...
24644385 - Prenatal diagnosis of granular cell tumor.
5318965 - Effects of a combination of atropine, metaraminol and pyridine aldoxime methanesulfonat...
22890625 - Caloric intake during the perioperative period and growth failure in infants with conge...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  70     ISSN:  1542-0752     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-26     Completed Date:  2004-12-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-93     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Wiley-Liss, Inc.
Affiliation:
National Institute of Child Health and Human Development, Rockville, Maryland, USA. jacksole@mail.nih.gov
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Female
Humans
Lead / adverse effects*
Male
Occupational Exposure / adverse effects
Pregnancy
Pulmonary Veins / abnormalities,  drug effects*
Grant Support
ID/Acronym/Agency:
R29-ES06218/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Developmental toxicity of methanol: Pathogenesis in CD-1 and C57BL/6J mice exposed in whole embryo c...
Next Document:  Risk for congenital anomalies associated with different sporadic and daily doses of alcohol consumpt...