Document Detail

Parental infertility and cerebral palsy in children.
MedLine Citation:
PMID:  21045245     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Children born after in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) have been reported to have a higher risk of cerebral palsy (CP), perhaps due to the higher frequency of preterm birth, multiple births or vanishing embryo in the pregnancies. However, it has been suggested that the underlying infertility may be part of the pathway. In this study, we examined whether untreated subfecundity (measured by time to pregnancy) or infertility treatment was associated with an increased risk of CP in the offspring.
METHODS: Using the Danish National Birth Cohort (1997-2003), we compared children born after 0-2 months of waiting time to pregnancy (n = 35 848) with those born after a time to pregnancy of 3-5 months (n = 15 361), 6-12 months (n = 11 528) and >12 months (n = 7387), as well as those born after IVF/ICSI (n = 3617), ovulation induction with or without intrauterine insemination (n = 3000), and unplanned pregnancies (n = 13 462). CP cases were identified through the Danish CP Register.
RESULTS: In total, 165 (0.18%) children were diagnosed with CP in the entire cohort. We found no significant association between time to pregnancy and the risk of CP in children conceived spontaneously. Children born after IVF/ICSI had an increased risk of CP, even after adjustment for preterm birth and multiplicity (hazard ratio 2.30, 95% confidence interval 1.12-4.73).
CONCLUSIONS: Subfecundity per se did not appear to be associated with the risk of CP in children, whereas being born after IVF/ICSI conferred an increased risk.
Jin Liang Zhu; Dorte Hvidtjørn; Olga Basso; Carsten Obel; Poul Thorsen; Peter Uldall; Jørn Olsen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2010-11-02
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  25     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-03-24     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  3142-5     Citation Subset:  IM    
The Danish Epidemiology Science Centre, Department of Epidemiology, School of Public Health, University of Aarhus, Aarhus C, Denmark.
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MeSH Terms
Cerebral Palsy / epidemiology,  etiology*
Child, Preschool
Denmark / epidemiology
Fertilization in Vitro / adverse effects
Infertility* / etiology
Reproductive Techniques, Assisted / adverse effects
Sperm Injections, Intracytoplasmic / adverse effects

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