Document Detail

Parental history of hypertension, sodium loading, and cardiovascular response to stress.
MedLine Citation:
PMID:  7480568     Owner:  NLM     Status:  MEDLINE    
Parental history of hypertension, dietary sodium, and psychological stress have all been implicated in the development of essential hypertension and may interact in elevating disease risk. The mechanism by which this might occur is unclear, but it may be related to changes in the peripheral vasculature. The present study examined the effects of parental history and sodium on cardiovascular responses to an extended stressor. Eighteen normotensive offspring of hypertensives and 18 offspring of normotensives were exposed to a 1-hour shock-avoidance video-game procedure after 14 days of sodium loading (10 1-g tablets/day) and again after 14 days of placebo tablets. Order of sessions was counterbalanced between subjects in a double-blind design. In offspring of hypertensives, sodium loading elevated total peripheral resistance and norepinephrine responses to stress relative to placebo conditions and compared with offspring of normotensives. These increases were accompanied by decreases in stroke volume and cardiac output, which may explain the absence of familial differences in blood pressure responses to stress and sodium. Sodium loading had no effect on offspring of normotensives. The elevated resistance in offspring of hypertensives may suggest the initiation of pathological processes. The absence of sodium effects on resting values indicates the importance of research under conditions of stress.
S B Miller; M Friese; A Sita
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychosomatic medicine     Volume:  57     ISSN:  0033-3174     ISO Abbreviation:  Psychosom Med     Publication Date:    1995 Jul-Aug
Date Detail:
Created Date:  1995-12-06     Completed Date:  1995-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  381-9     Citation Subset:  IM    
Department of Psychology, Concordia University, Montreal, Quebec, Canada.
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MeSH Terms
Arousal / genetics*,  physiology
Avoidance Learning / physiology
Double-Blind Method
Hypertension / genetics*,  physiopathology
Muscle, Smooth, Vascular / innervation*
Problem Solving / physiology
Psychomotor Performance / physiology
Risk Factors
Sodium / blood*
Stress, Psychological / complications*,  physiopathology
Sympathetic Nervous System / physiopathology
Vascular Resistance / physiology
Water-Electrolyte Balance / genetics*,  physiology
Reg. No./Substance:

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