| Parental genomic imprinting of the human IGF2 gene. | |
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MedLine Citation:
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PMID: 8099843 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mouse igf2 gene, coding for the insulin-like growth factor II (IGF-II) is parentally imprinted, only the gene copy derived from the father is expressed. To know whether IGF2, the human homologue, is also imprinted, we used an ApaI polymorphism at the 3' untranslated region in order to distinguish between mRNA derived from each copy of the gene in placentae from heterozygote human fetuses, studied after careful removal of the decidua. Six term and two pre-term placentae of heterozygotes were studied, and in each case the cDNA contained only one of the two alleles present in the genomic DNA. In three cases the mother was homozygous for the non-expressed allele, allowing assignment of paternal origin to the transcribed gene copy. We conclude that, as in the mouse, human IGF2 is parentally imprinted. |
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Authors:
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N Giannoukakis; C Deal; J Paquette; C G Goodyer; C Polychronakos |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nature genetics Volume: 4 ISSN: 1061-4036 ISO Abbreviation: Nat. Genet. Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-07-19 Completed Date: 1993-07-19 Revised Date: 2008-08-28 |
Medline Journal Info:
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Nlm Unique ID: 9216904 Medline TA: Nat Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 98-101 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, McGill University, Montréal, Québec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Animals Base Sequence Deoxyribonucleases, Type II Site-Specific Gene Expression Regulation* Gestational Age Heterozygote Humans Insulin-Like Growth Factor II / genetics* Mice / genetics Molecular Sequence Data Parents Placenta / chemistry Polymorphism, Restriction Fragment Length Prader-Willi Syndrome / genetics RNA, Messenger / genetics Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 67763-97-7/Insulin-Like Growth Factor II; EC 3.1.21.4/Deoxyribonucleases, Type II Site-Specific; EC 3.1.21.4/GGGCCC-specific type II deoxyribonucleases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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