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Parental, fetal and infant risk factors for preschool overweight: The Generation R Study.
MedLine Citation:
PMID:  23138398     Owner:  NLM     Status:  Publisher    
Background:Overweight has its origins largely in early life. We aimed to identify the most important parental, fetal and infant risk factors of preschool overweight.Methods:In a prospective cohort study, among 3,610 Caucasian preschool children, we assessed the associations of 34 putative parental, fetal and infant factors with overweight risk.Results:Higher maternal BMI, paternal BMI and birth weight were associated with higher risk of preschool overweight (OR 1.23, 95% CI 1.10, 1.39, OR 1.35, 95% CI 1.19, 1.53 and OR 2.71, 95% CI 2.27, 3.25 respectively per SD increase). The same model identified low household income (OR 1.74, 95% CI 1.24, 2.45), being female (OR 1.55, 95% CI 1.20, 2.01), experiencing third trimester accelerated growth (OR 1.73, 95% CI 1.24, 2.40) or postnatal accelerated growth (OR 6.39, 95% CI 4.54, 8.99) as risk factors of preschool overweight. Higher poly unsaturated fat intake at 14 months was associated with lower risk of preschool overweight (OR 0.77, 95% CI 0.62, 0.96 per SD).Conclusion:Parental anthropometrics and household income, fetal and infant accelerated growth, and infant dietary fat intake are the major risk factors for development of pre-school overweight. Further studies need to explore whether these risk factors could be potential targets for preventive interventions.Pediatric Research (2012); doi:10.1038/pr.2012.145.
Denise H M Heppe; Jessica C Kiefte-de Jong; Büşra Durmuş; Henriëtte A Moll; Hein Raat; Albert Hofman; Vincent W V Jaddoe
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-08
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1] The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands [2] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands [3] Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands.
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