Document Detail

Parental decisions regarding prenatally detected fetal sex chromosomal abnormality and the impact of genetic counselling: an analysis of 57 cases in Taiwan.
MedLine Citation:
PMID:  18366488     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To analyse parental decisions regarding pregnancies with sex chromosome abnormalities (SCA). METHODS: Collected and reviewed records from our hospital for 1991-2005. Genetic counselling was provided by obstetricians or perinatologists. RESULT: Among 57 fetuses with SCA were 36 non-mosaic cases (four of 36, 45,X; 12 of 36, 47,XXY; seven of 36, 47,XYY, 13 of 36, 47,XXX) and 21 mosaic cases (15 of 21, 45,X mosaicism). Only 20% of 45,X mosaic pregnancies were continued, whereas all other mosaic pregnancies (100%) were continued (P = 0.004). Of 32 SCA cases counselled by a perinatologist, 66% (21 of 32) were continued. In contrast, 36% (nine of 25) of cases counselled by a general obstetrician were continued, a barely significant difference (P = 0.048). More couples chose to continue pregnancies in recent years. CONCLUSION: Genetic counselling by well-trained specialists is valuable, and the trend towards fewer terminations at our centre suggests improved parental knowledge of pathology associated with SCA.
Sheng-Wen Shaw; Ho-Yen Chueh; Shuenn-Dyh Chang; Po-Jen Cheng; T'sang-T'ang Hsieh; Yung-Kuei Soong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  48     ISSN:  0004-8666     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-27     Completed Date:  2008-08-21     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  155-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, Tao-Yuan, Taiwan.
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MeSH Terms
Abortion, Eugenic / psychology
Decision Making*
Genetic Counseling*
Parents / psychology*
Prenatal Diagnosis* / psychology
Retrospective Studies
Sex Chromosome Disorders / diagnosis,  psychology*,  therapy
Erratum In:
Aust N Z J Obstet Gynaecol. 2008 Jun;48(3):235

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