Document Detail

Parental age and the origin of extra chromosome 21 in Down syndrome.
MedLine Citation:
PMID:  11393539     Owner:  NLM     Status:  MEDLINE    
We present a report of the parental ages (n = 865) and parental origin of meiotic nondisjunction (n = 236) that are likely to show a predisposition in the etiology of Down syndrome (DS). Chromosomal analysis, performed over a 20-year period, on 1,001 Down syndrome subjects, revealed pure trisomy 21 karyotype in 880 subjects (87.92%), mosaic trisomy karyotype in 77 (7.69%), and translocation karyotype in 44 (4.39%). The mean maternal age was found to be 30.34 years, and mean paternal age was 31.04 years. Nondisjunctional error was 79.24% maternal and 20.76% paternal. The findings of the study revealed the significant contribution of advanced parental age and increased maternal meiotic nondisjunctional error to the origin of trisomy 21 Down syndrome.
A Jyothy; K S Kumar; G N Mallikarjuna; V Babu Rao; B Uma Devi; M Sujatha; P P Reddy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of human genetics     Volume:  46     ISSN:  1434-5161     ISO Abbreviation:  J. Hum. Genet.     Publication Date:  2001  
Date Detail:
Created Date:  2001-06-06     Completed Date:  2001-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9808008     Medline TA:  J Hum Genet     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  347-50     Citation Subset:  IM    
Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, India.
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MeSH Terms
Chromosomes, Human, Pair 21 / genetics*
Down Syndrome / genetics*
Maternal Age
Meiosis / genetics
Middle Aged
Paternal Age
Translocation, Genetic

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