| Parental age and the origin of extra chromosome 21 in Down syndrome. | |
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MedLine Citation:
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PMID: 11393539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present a report of the parental ages (n = 865) and parental origin of meiotic nondisjunction (n = 236) that are likely to show a predisposition in the etiology of Down syndrome (DS). Chromosomal analysis, performed over a 20-year period, on 1,001 Down syndrome subjects, revealed pure trisomy 21 karyotype in 880 subjects (87.92%), mosaic trisomy karyotype in 77 (7.69%), and translocation karyotype in 44 (4.39%). The mean maternal age was found to be 30.34 years, and mean paternal age was 31.04 years. Nondisjunctional error was 79.24% maternal and 20.76% paternal. The findings of the study revealed the significant contribution of advanced parental age and increased maternal meiotic nondisjunctional error to the origin of trisomy 21 Down syndrome. |
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Authors:
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A Jyothy; K S Kumar; G N Mallikarjuna; V Babu Rao; B Uma Devi; M Sujatha; P P Reddy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of human genetics Volume: 46 ISSN: 1434-5161 ISO Abbreviation: J. Hum. Genet. Publication Date: 2001 |
Date Detail:
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Created Date: 2001-06-06 Completed Date: 2001-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9808008 Medline TA: J Hum Genet Country: Japan |
Other Details:
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Languages: eng Pagination: 347-50 Citation Subset: IM |
Affiliation:
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Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, India. ksdkumar@rediffmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chromosomes, Human, Pair 21 / genetics* Down Syndrome / genetics* Female Humans India Male Maternal Age Meiosis / genetics Middle Aged Mosaicism Paternal Age Translocation, Genetic |
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