Document Detail

Parental GM and HLA genotypes and reduced birth weight in patients with Turner's syndrome.
MedLine Citation:
PMID:  12387517     Owner:  NLM     Status:  MEDLINE    
We investigated a possible influence on birth weight in Turner's syndrome of many clinical, hormonal, genetic and immunogenetic variables. We considered 97 patients with Turner's syndrome. Patients with parents with identical GM (Gamma heavy chains Marker) phenotype had a significantly lower birth weight than those with parents with different GM phenotype. Karyotype other than 45,X, HLA (Human Leukocyte Antigen) parental sharing, mother-patient compatibility and elevated 17-hydroxyprogesterone (17OHP) serum level after adrenocorticotropin hormone (ACTH) and absence of heart and kidney malformations and lymphedema were associated with a lower birth weight, but not significantly. Multiple interactions showed that the presence of an identical GM phenotype in parents, together with other conditions (karyotype other than 45,X, adrenal dysfunction, HLA parental sharing, mother-child compatibility, KM(3) [Kappa light chains Marker] phenotype) resulted in a further decrease of birth weight. These data might suggest a negative effect of genetic similarity on intrauterine growth in Turner's syndrome.
Daniela Larizza; Miryam Martinetti; Jean Michel Dugoujon; Carmine Tinelli; Valeria Calcaterra; Mariaclara Cuccia; Laura Salvaneschi; Francesca Severi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  15     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:    2002 Sep-Oct
Date Detail:
Created Date:  2002-10-21     Completed Date:  2003-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  1183-90     Citation Subset:  IM    
Department of Pediatrics, University of Pavia, Italy.
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MeSH Terms
17-alpha-Hydroxyprogesterone / blood
Adrenocorticotropic Hormone / diagnostic use
Birth Order
Birth Weight / genetics*
Gestational Age
HLA Antigens / genetics*
Heart Defects, Congenital / genetics
Immunoglobulin gamma-Chains / genetics*
Immunoglobulin kappa-Chains / genetics
Infant, Newborn
Kidney / abnormalities
Turner Syndrome / genetics*
Reg. No./Substance:
0/HLA Antigens; 0/Immunoglobulin gamma-Chains; 0/Immunoglobulin kappa-Chains; 68-96-2/17-alpha-Hydroxyprogesterone; 9002-60-2/Adrenocorticotropic Hormone

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