Document Detail


Parent-specific complementary patterns of histone H3 lysine 9 and H3 lysine 4 methylation at the Prader-Willi syndrome imprinting center.
MedLine Citation:
PMID:  11592036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Prader-Willi syndrome (PWS)/Angelman syndrome (AS) region, on human chromosome 15q11-q13, exemplifies coordinate control of imprinted gene expression over a large chromosomal domain. Establishment of the paternal state of the region requires the PWS imprinting center (PWS-IC); establishment of the maternal state requires the AS-IC. Cytosine methylation of the PWS-IC, which occurs during oogenesis in mice, occurs only after fertilization in humans, so this modification cannot be the gametic imprint for the PWS/AS region in humans. Here, we demonstrate that the PWS-IC shows parent-specific complementary patterns of H3 lysine 9 (Lys9) and H3 lysine 4 (Lys4) methylation. H3 Lys9 is methylated on the maternal copy of the PWS-IC, and H3 Lys4 is methylated on the paternal copy. We suggest that H3 Lys9 methylation is a candidate maternal gametic imprint for this region, and we show how changes in chromatin packaging during the life cycle of mammals provide a means of erasing such an imprint in the male germline.
Authors:
Z Xin; C D Allis; J Wagstaff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2001-10-04
Journal Detail:
Title:  American journal of human genetics     Volume:  69     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-11-12     Completed Date:  2002-01-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1389-94     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA, USA.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Chromosomes, Human, Pair 15 / genetics*
DNA Methylation*
Exons / genetics
Female
Genomic Imprinting / genetics*
Germ Cells / metabolism
Histones / chemistry*,  genetics*
Humans
Lysine / genetics,  metabolism*
Male
Models, Genetic
Prader-Willi Syndrome / genetics*,  metabolism
Promoter Regions, Genetic / genetics
Chemical
Reg. No./Substance:
0/Histones; 56-87-1/Lysine
Comments/Corrections

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