| Parent-specific complementary patterns of histone H3 lysine 9 and H3 lysine 4 methylation at the Prader-Willi syndrome imprinting center. | |
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MedLine Citation:
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PMID: 11592036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Prader-Willi syndrome (PWS)/Angelman syndrome (AS) region, on human chromosome 15q11-q13, exemplifies coordinate control of imprinted gene expression over a large chromosomal domain. Establishment of the paternal state of the region requires the PWS imprinting center (PWS-IC); establishment of the maternal state requires the AS-IC. Cytosine methylation of the PWS-IC, which occurs during oogenesis in mice, occurs only after fertilization in humans, so this modification cannot be the gametic imprint for the PWS/AS region in humans. Here, we demonstrate that the PWS-IC shows parent-specific complementary patterns of H3 lysine 9 (Lys9) and H3 lysine 4 (Lys4) methylation. H3 Lys9 is methylated on the maternal copy of the PWS-IC, and H3 Lys4 is methylated on the paternal copy. We suggest that H3 Lys9 methylation is a candidate maternal gametic imprint for this region, and we show how changes in chromatin packaging during the life cycle of mammals provide a means of erasing such an imprint in the male germline. |
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Authors:
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Z Xin; C D Allis; J Wagstaff |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2001-10-04 |
Journal Detail:
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Title: American journal of human genetics Volume: 69 ISSN: 0002-9297 ISO Abbreviation: Am. J. Hum. Genet. Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-11-12 Completed Date: 2002-01-10 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370475 Medline TA: Am J Hum Genet Country: United States |
Other Details:
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Languages: eng Pagination: 1389-94 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Chromosomes, Human, Pair 15 / genetics* DNA Methylation* Exons / genetics Female Genomic Imprinting / genetics* Germ Cells / metabolism Histones / chemistry*, genetics* Humans Lysine / genetics, metabolism* Male Models, Genetic Prader-Willi Syndrome / genetics*, metabolism Promoter Regions, Genetic / genetics |
| Chemical | |
Reg. No./Substance:
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0/Histones; 56-87-1/Lysine |
| Comments/Corrections | |
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