Document Detail


Parent-of-origin specific linkage and association of the IGF2 gene region with birth weight and adult metabolic risk factors.
MedLine Citation:
PMID:  19546867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The maternally imprinted insulin-like growth factor 2 (IGF2) gene is an important fetal growth factor and is also suggested to have postnatal metabolic effects. In this study, we examined whether common polymorphisms in IGF2 (6815_6819delAGGGC, 1156T>C and 820G>A (ApaI)) and a microsatellite marker in the close vicinity of IGF2 were linked to or associated with birth weight and adult metabolic risk factors.
DESIGN AND PARTICIPANTS: Polymorphisms were genotyped in 199 monozygotic complete twin pairs, 109 dizygotic complete twin pairs, 15 single twins, 231 mothers and 228 fathers recruited from the East Flanders Prospective Twin Survey. Conventional and parent-of-origin specific linkage and association analyses were carried out with birth weight, adult body height and parameters quantifying obesity, insulin sensitivity and dyslipidaemia measured at adult age (mean age 25 years).
RESULTS: In the parent-of-origin specific association analysis, in which only the paternally inherited allele was incorporated, the 1156T>C SNP (single nucleotide polymorphism) showed significant association with IGF-binding protein 1 (IGFBP1) levels (T and C (mean (95% CI)): 13.2 (12.1-14.3) and 16.2 (14.6-18.0) ng ml(-1), P=0.002). No linkage was observed in either the conventional or in the parent-of-origin specific linkage analysis.
CONCLUSION: This study suggests that paternally inherited alleles of a common polymorphism in the IGF2 gene affect IGFBP1 levels.
Authors:
N Y Souren; A D C Paulussen; A Steyls; R J F Loos; R D Brandao; M Gielen; H J M Smeets; G Beunen; R Fagard; C Derom; R Vlietinck; J P Geraedts; M P Zeegers
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study     Date:  2009-06-23
Journal Detail:
Title:  International journal of obesity (2005)     Volume:  33     ISSN:  1476-5497     ISO Abbreviation:  Int J Obes (Lond)     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-14     Completed Date:  2010-10-22     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  101256108     Medline TA:  Int J Obes (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  962-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Belgium / epidemiology
Birth Weight / genetics*
Diseases in Twins / genetics
Female
Genetic Linkage / genetics*
Genetic Predisposition to Disease / epidemiology,  genetics*
Genotype
Humans
Infant, Newborn
Insulin-Like Growth Factor II / genetics*,  metabolism
Male
Metabolic Diseases / epidemiology,  genetics*
Microsatellite Repeats / genetics*
Polymorphism, Single Nucleotide
Pregnancy
Risk Factors
Twins, Monozygotic / genetics
Grant Support
ID/Acronym/Agency:
MC_U106188470//Medical Research Council
Chemical
Reg. No./Substance:
67763-97-7/Insulin-Like Growth Factor II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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