Document Detail


Parent and teacher ratings of attention during a year-long methylphenidate trial in children treated for cancer.
MedLine Citation:
PMID:  21097489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Longitudinally examine attention performance in childhood cancer survivors prescribed methylphenidate (MPH) to ameliorate cognitive late effects, comparing measures for inter-rater and inter-method discrepancies.
METHODS: Survivors of acute lymphoblastic leukemia (n = 33) or brain tumor (n = 35), mean age 11.11 ± 0.37 years, completed a 12-month, open-label trial of MPH. Conners' Parent and Teacher Rating Scales were completed at baseline, 1, 3, 6, and 12 months. The Conners' Continuous Performance Test (CPT) was completed at baseline and 12 months.
RESULTS: Improved attention was reported after 1 month of MPH (p < .05), with relative stability throughout the trial. Inter-rater agreement was low-to-moderate (ICC = -.06 to .46). Observer ratings correlated with select CPT indices at baseline (p < .05), but not at 12 months.
CONCLUSIONS: Childhood cancer survivors' attention improved after 1 month on MPH. Modest agreement between parents and teachers, and low-to-moderate correlations between behavior ratings and performance-based attention measures highlight a need for multimodal assessment.
Authors:
Kelli L Netson; Heather M Conklin; Jason M Ashford; Lisa S Kahalley; Shengie Wu; Xiaoping Xiong
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-11-19
Journal Detail:
Title:  Journal of pediatric psychology     Volume:  36     ISSN:  1465-735X     ISO Abbreviation:  J Pediatr Psychol     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-20     Completed Date:  2011-08-15     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7801773     Medline TA:  J Pediatr Psychol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  438-50     Citation Subset:  IM    
Affiliation:
Department of Psychology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 740, Memphis, TN 38105, USA. heather.conklin@stjude.org
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MeSH Terms
Descriptor/Qualifier:
Attention / drug effects*
Attention Deficit Disorder with Hyperactivity / drug therapy
Central Nervous System Stimulants / administration & dosage,  therapeutic use*
Child
Educational Status
Faculty
Female
Humans
Male
Methylphenidate / administration & dosage,  therapeutic use*
Neoplasms / psychology*
Neuropsychological Tests
Parents
Questionnaires
Survivors
Treatment Outcome
Grant Support
ID/Acronym/Agency:
P30 CA21765/CA/NCI NIH HHS; R01 CA78957/CA/NCI NIH HHS; U01 CA81445/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Central Nervous System Stimulants; 113-45-1/Methylphenidate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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