| Paraventricular nucleus neuropeptide expression in Huntington's disease patients. | |
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MedLine Citation:
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PMID: 22257050 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Neuroendocrine, metabolic and autonomic nervous system dysfunction are prevalent among patients with Huntington's disease (HD) and may underlie symptoms such as depression, weight loss and autonomic failure. Using post-mortem paraffin embedded tissue, we assessed the integrity of the major neuropeptide populations in the paraventricular nucleus (PVN) - the hypothalamic neuroendocrine and autonomic integration center - in HD patients. The number corticotropin-releasing hormone, cocaine- and amphetamine- regulated transcript, arginine vasopressin and oxytocin immunoreactive neurons did not differ between HD patients and control subjects. However, the significant positive correlation between arginine vasopressin and oxytocin immunoreactive neurons in control subjects (P = 0.036), was absent in patients. Corticotropin-releasing hormone mRNA levels were 68% higher in HD patients (P = 0.046). Thyrotropin-releasing hormone mRNA levels were did not differ between HD patients and controls subjects, although a negative correlation with disease duration was present in the former (P = 0.036). These findings indicate that the PVN is largely unaffected in HD patients. However, our findings suggest that hypothalamic-pituitary-thyroid axis activity may alter during the course of the disease and that autonomic nervous system dysfunction might partly arise from an imbalance between arginine vasopressin and oxytocin neurons in the PVN. |
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Authors:
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Daniel J van Wamelen; N Ahmad Aziz; Jasper J Anink; Raymund A C Roos; Dick F Swaab |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
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Title: Brain pathology (Zurich, Switzerland) Volume: - ISSN: 1750-3639 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9216781 Medline TA: Brain Pathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors; Brain Pathology © 2012 International Society of Neuropathology. |
Affiliation:
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Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105BA, Amsterdam ZO, the Netherlands. Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2333ZA Leiden, the Netherlands. |
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