Document Detail

Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion.
MedLine Citation:
PMID:  3841735     Owner:  NLM     Status:  MEDLINE    
Neuropeptide Y (NPY) injected into the paraventricular nucleus (PVN) is known to elicit a powerful feeding response in satiated, brain-cannulated rats. The present experiment investigates the effect of peptide YY (PYY), a structurally-related peptide, on feeding behavior and, in addition, the effects of both PYY and NPY on the pattern of macronutrient selection. Injection of PYY directly into the PVN, in doses ranging from 7.8 to 235 pmol/0.3 microliters, caused a strong, dose-dependent stimulation of feeding behavior, as well as a small stimulation of drinking behavior, in satiated rats. The mean latency to eat was 9.3 min, with substantial feeding occurring within 30 min of the injection. At low doses, the increase in feeding was seen predominantly during the first hr. At the highest dose, in contrast, food intake continued to increase progressively over the next few hr. such that by 4 hr postinjection food intake was more than 20 g over vehicle baseline. In 1 hr tests with 3 pure macronutrient (protein, fat and carbohydrate) diets simultaneously available, PYY and NPY (78 pmol/0.3 microliters) both elicited a strong and selective increase in carbohydrate consumption, with little or no effect on protein or fat consumption. These results suggest that hypothalamic receptors sensitive to PYY and NPY may participate in the control of carbohydrate consumption.
B G Stanley; D R Daniel; A S Chin; S F Leibowitz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  6     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1985 Nov-Dec
Date Detail:
Created Date:  1986-05-23     Completed Date:  1986-05-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1205-11     Citation Subset:  IM    
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MeSH Terms
Dietary Carbohydrates*
Drinking Behavior / drug effects
Feeding Behavior / drug effects
Gastrointestinal Hormones / pharmacology*
Nerve Tissue Proteins / pharmacology*
Neuropeptide Y
Paraventricular Hypothalamic Nucleus / drug effects,  physiology*
Peptide YY
Peptides / pharmacology*
Rats, Inbred Strains
Vasoconstrictor Agents / pharmacology*
Grant Support
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Gastrointestinal Hormones; 0/Nerve Tissue Proteins; 0/Neuropeptide Y; 0/Peptides; 0/Vasoconstrictor Agents; 106388-42-5/Peptide YY

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