Document Detail


Parathyroid tumor development involves deregulation of homeobox genes.
MedLine Citation:
PMID:  18310293     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant syndrome caused by mutations in the MEN1 tumor suppressor gene. Loss of the functional second copy of the MEN1 gene causes individuals to develop multiple endocrine tumors, primarily affecting the parathyroid, pituitary, and pancreas. While it is clear that the protein encoded by MEN1, menin, suppresses endocrine tumors, its biochemical functions and direct downstream targets remain unclear. Recent studies have suggested that menin may act as a scaffold protein to coordinate gene transcription, and that menin is an oncogenic cofactor for homeobox (HOX) gene expression in hematopoietic cancer. The role of HOX genes in adult cell differentiation is still obscure, but growing evidence suggests that they may play important roles in the development of cancer. Therefore, we hypothesized that specific HOX genes were regulated by menin in parathyroid tumor development. Utilizing quantitative TaqMan RT-PCR, we compared expression profiles of the 39 HOX genes in human familial MEN1 (fMEN1) parathyroid tumors and sporadic parathyroid adenomas with normal samples. We identified a large set of 23 HOX genes whose deregulation is specific for fMEN1 parathyroid tumors, and only 5 HOX genes whose misexpression are specific for sporadic parathyroid tumor development. These findings provide the first evidence that loss of the MEN1 tumor suppressor gene is associated with deregulation of specific HOX gene expression in the development of familial human parathyroid tumors. Our results strongly reinforce the idea that abnormal expression of developmental HOX genes can be critical in human cancer progression.
Authors:
H-C Jennifer Shen; Jennifer E Rosen; Lauren M Yang; Sharon A Savage; A Lee Burns; Carmen M Mateo; Sunita K Agarwal; Settara C Chandrasekharappa; Allen M Spiegel; Francis S Collins; Stephen J Marx; Steven K Libutti
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Endocrine-related cancer     Volume:  15     ISSN:  1351-0088     ISO Abbreviation:  Endocr. Relat. Cancer     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-05-08     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  9436481     Medline TA:  Endocr Relat Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  267-75     Citation Subset:  IM    
Affiliation:
Tumor Angiogenesis Section, Surgery Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Female
Gene Expression Regulation, Neoplastic
Genes, Homeobox / genetics*
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Multiple Endocrine Neoplasia Type 1 / genetics*,  metabolism,  pathology
Mutation / genetics*
Parathyroid Neoplasms / genetics,  metabolism*,  pathology*
Proto-Oncogene Proteins / genetics*,  metabolism
RNA, Messenger / genetics,  metabolism
Reverse Transcriptase Polymerase Chain Reaction
Grant Support
ID/Acronym/Agency:
ZIA CP010142-11/CP/NCI NIH HHS
Chemical
Reg. No./Substance:
0/MEN1 protein, human; 0/Proto-Oncogene Proteins; 0/RNA, Messenger
Comments/Corrections

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