Document Detail

Parathyroid hormone-stimulated calcium absorption in cTAL from vitamin D-deficient rabbits.
MedLine Citation:
PMID:  3586497     Owner:  NLM     Status:  MEDLINE    
Cortical thick ascending limbs of Henle's loop were dissected from the kidneys of chronically vitamin D-deficient or -replete rabbits and perfused in vitro. Unidirectional transepithelial calcium fluxes from lumen to bath were measured with 45Ca. The tubules were bathed in a solution containing 150 mM sodium and perfused with a solution containing 60 mM sodium to simulate conditions in the cortical thick ascending limb in vivo. Transepithelial voltages were equal across tubules from vitamin D-deficient and -replete rabbits. Likewise, baseline and parathyroid hormone-stimulated calcium fluxes were the same in tubules from the two groups. Because calcidiol and calcitriol were undetectable in the serum of the vitamin D-deficient rabbits, we suggest that neither of these endogenous vitamin D metabolites is essential in the regulation of calcium absorption in this portion of the rabbit nephron.
J E Bourdeau; C B Langman; R Bouillon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Kidney international     Volume:  31     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-22     Completed Date:  1987-07-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  913-7     Citation Subset:  IM    
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MeSH Terms
Biological Transport, Active / drug effects
Calcium / metabolism*
Kidney Tubules / metabolism*
Loop of Henle / drug effects,  metabolism*
Parathyroid Hormone / blood,  pharmacology*
Vitamin D Deficiency / metabolism*
Grant Support
Reg. No./Substance:
0/Parathyroid Hormone; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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