Document Detail

Parathyroid hormone secretion and serum calcium concentration--a deterministic view of its regulation.
MedLine Citation:
PMID:  7642177     Owner:  NLM     Status:  MEDLINE    
In seven normal men we investigated the basal secretion of PTH by blood sampling in 30 sec intervals for estimation of intact PTH and at 2-min intervals for measurement of ionized calcium. In 4 of these subjects we also investigated the PTH-secretion under conditions of intermittent hypercalcemia and hypocalcemia. Our measurements demonstrate the existence of three time scales in the secretion of PTH, viz. short-term pulses (faster than 2 min), an intermediate pattern of adjusting PTH levels to changed Ca2+ averages, and finally a long-term coupling between PTH and Ca2+ averages after 20 min. Ionized calcium controls the long-term regulation and intermediate adaptation mechanisms, but the short-term fluctuations seem to be due to spontaneous secretion.
E Heidbreder; H Naujoks; U Brosa; L Schramm; R Götz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  27     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-09-21     Completed Date:  1995-09-21     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  244-50     Citation Subset:  IM    
Nephrologische Abteilung Medizinische Universitätsklinik, Würzburg, Germany.
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MeSH Terms
Calcium / blood*
Parathyroid Hormone / blood,  secretion*
Reg. No./Substance:
0/Parathyroid Hormone; 7440-70-2/Calcium

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