Document Detail

Parathyroid hormone response to vitamin D insufficiency in elderly males with chronic heart failure.
MedLine Citation:
PMID:  21777017     Owner:  NLM     Status:  MEDLINE    
Secondary hyperparathyroidism (SHPT) may contribute to the systemic illness that accompanies chronic heart failure (CHF). Healthy elderly with vitamin D deficiency who did not develop hyperparathyroidism (functional hypoparathyroidism, FHPT) had lower mortality than those who did. This study was designed to examine determinants of the PTH response in the vitamin D insufficient CHF patients. Sixty five vitamin D insufficient males with NYHA class II and III and 20 control subjects age >/=55 years were recruited. Echocardiography, physical performance, NT-pro-BNP, PTH, 25-hydroxyvitamin D (25(OH)D), adiponectin and bone activity surrogate markers (OPG, RANKL, OC, beta-CTx) were assessed. Increased NYHA class was associated with SHPT, while physical performance was inferior compared to FHPT. SHPT was associated with lower left ventricular ejection fraction (LVEF) and flow mediated dilatation, but with higher left heart dimensions, left ventricular mass index and right ventricular systolic pressure. CHF patients with SHPT had increased NT-pro-BNP, adiponectin and bone markers, but decreased 25(OH)D compared to those with FHPT. Independent determinants for SHPT in CHF patients with vitamin D insufficiency were LVEF, adiponectin and beta-CTx, irrespective of renal function and serum vitamin D levels. In conclusion, increased PTH levels, but not low vitamin D, demonstrated close relation to CHF severity.
B Bozic; G Loncar; N Prodanovic; T Lepic; Z Radojicic; V Cvorovic; S Dimkovic; V Popovic
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-07-19
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  60 Suppl 1     ISSN:  1802-9973     ISO Abbreviation:  Physiol Res     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-14     Completed Date:  2012-02-07     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  S155-63     Citation Subset:  IM    
Institute for Medical Research, Military Medical Academy, Belgrade, Serbia.
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MeSH Terms
Absorptiometry, Photon
Adiponectin / blood
Age Factors
Analysis of Variance
Biological Markers / blood
Body Composition
Bone Density
Case-Control Studies
Chi-Square Distribution
Chronic Disease
Collagen / blood
Cross-Sectional Studies
Echocardiography, Doppler
Exercise Test
Heart Failure / blood,  complications*,  diagnosis
Hyperparathyroidism, Secondary / blood,  complications*,  diagnosis
Hypoparathyroidism / blood,  complications*,  diagnosis
Logistic Models
Middle Aged
Odds Ratio
Parathyroid Hormone / blood*
Peptide Fragments / blood
Risk Assessment
Risk Factors
Severity of Illness Index
Stroke Volume
Ventricular Function, Left
Vitamin D / blood
Vitamin D Deficiency / blood,  complications*,  diagnosis
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Biological Markers; 0/PTH protein, human; 0/Parathyroid Hormone; 0/Peptide Fragments; 0/glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; 1406-16-2/Vitamin D; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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