| Parathyroid hormone response to vitamin D insufficiency in elderly males with chronic heart failure. | |
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MedLine Citation:
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PMID: 21777017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Secondary hyperparathyroidism (SHPT) may contribute to the systemic illness that accompanies chronic heart failure (CHF). Healthy elderly with vitamin D deficiency who did not develop hyperparathyroidism (functional hypoparathyroidism, FHPT) had lower mortality than those who did. This study was designed to examine determinants of the PTH response in the vitamin D insufficient CHF patients. Sixty five vitamin D insufficient males with NYHA class II and III and 20 control subjects age >/=55 years were recruited. Echocardiography, physical performance, NT-pro-BNP, PTH, 25-hydroxyvitamin D (25(OH)D), adiponectin and bone activity surrogate markers (OPG, RANKL, OC, beta-CTx) were assessed. Increased NYHA class was associated with SHPT, while physical performance was inferior compared to FHPT. SHPT was associated with lower left ventricular ejection fraction (LVEF) and flow mediated dilatation, but with higher left heart dimensions, left ventricular mass index and right ventricular systolic pressure. CHF patients with SHPT had increased NT-pro-BNP, adiponectin and bone markers, but decreased 25(OH)D compared to those with FHPT. Independent determinants for SHPT in CHF patients with vitamin D insufficiency were LVEF, adiponectin and beta-CTx, irrespective of renal function and serum vitamin D levels. In conclusion, increased PTH levels, but not low vitamin D, demonstrated close relation to CHF severity. |
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Authors:
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B Bozic; G Loncar; N Prodanovic; T Lepic; Z Radojicic; V Cvorovic; S Dimkovic; V Popovic |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-07-19 |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 60 Suppl 1 ISSN: 1802-9973 ISO Abbreviation: Physiol Res Publication Date: 2011 |
Date Detail:
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Created Date: 2011-10-14 Completed Date: 2012-02-07 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: Czech Republic |
Other Details:
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Languages: eng Pagination: S155-63 Citation Subset: IM |
Affiliation:
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Institute for Medical Research, Military Medical Academy, Belgrade, Serbia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adiponectin / blood Age Factors Aged Analysis of Variance Biological Markers / blood Body Composition Bone Density Case-Control Studies Chi-Square Distribution Chronic Disease Collagen / blood Cross-Sectional Studies Echocardiography, Doppler Exercise Test Heart Failure / blood, complications*, diagnosis Humans Hyperparathyroidism, Secondary / blood, complications*, diagnosis Hypoparathyroidism / blood, complications*, diagnosis Logistic Models Male Middle Aged Odds Ratio Parathyroid Hormone / blood* Peptide Fragments / blood Prognosis Questionnaires Risk Assessment Risk Factors Serbia Severity of Illness Index Stroke Volume Ventricular Function, Left Vitamin D / blood Vitamin D Deficiency / blood, complications*, diagnosis |
| Chemical | |
Reg. No./Substance:
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0/ADIPOQ protein, human; 0/Adiponectin; 0/Biological Markers; 0/PTH protein, human; 0/Parathyroid Hormone; 0/Peptide Fragments; 0/glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; 1406-16-2/Vitamin D; 9007-34-5/Collagen |
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