|Parathyroid hormone response to vitamin D insufficiency in elderly males with chronic heart failure.|
|PMID: 21777017 Owner: NLM Status: MEDLINE|
|Secondary hyperparathyroidism (SHPT) may contribute to the systemic illness that accompanies chronic heart failure (CHF). Healthy elderly with vitamin D deficiency who did not develop hyperparathyroidism (functional hypoparathyroidism, FHPT) had lower mortality than those who did. This study was designed to examine determinants of the PTH response in the vitamin D insufficient CHF patients. Sixty five vitamin D insufficient males with NYHA class II and III and 20 control subjects age >/=55 years were recruited. Echocardiography, physical performance, NT-pro-BNP, PTH, 25-hydroxyvitamin D (25(OH)D), adiponectin and bone activity surrogate markers (OPG, RANKL, OC, beta-CTx) were assessed. Increased NYHA class was associated with SHPT, while physical performance was inferior compared to FHPT. SHPT was associated with lower left ventricular ejection fraction (LVEF) and flow mediated dilatation, but with higher left heart dimensions, left ventricular mass index and right ventricular systolic pressure. CHF patients with SHPT had increased NT-pro-BNP, adiponectin and bone markers, but decreased 25(OH)D compared to those with FHPT. Independent determinants for SHPT in CHF patients with vitamin D insufficiency were LVEF, adiponectin and beta-CTx, irrespective of renal function and serum vitamin D levels. In conclusion, increased PTH levels, but not low vitamin D, demonstrated close relation to CHF severity.|
|B Bozic; G Loncar; N Prodanovic; T Lepic; Z Radojicic; V Cvorovic; S Dimkovic; V Popovic|
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|Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-07-19|
|Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 60 Suppl 1 ISSN: 1802-9973 ISO Abbreviation: Physiol Res Publication Date: 2011|
|Created Date: 2011-10-14 Completed Date: 2012-02-07 Revised Date: 2012-04-09|
Medline Journal Info:
|Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: Czech Republic|
|Languages: eng Pagination: S155-63 Citation Subset: IM|
|Institute for Medical Research, Military Medical Academy, Belgrade, Serbia.|
|APA/MLA Format Download EndNote Download BibTex|
Adiponectin / blood
Analysis of Variance
Biological Markers / blood
Collagen / blood
Heart Failure / blood, complications*, diagnosis
Hyperparathyroidism, Secondary / blood, complications*, diagnosis
Hypoparathyroidism / blood, complications*, diagnosis
Parathyroid Hormone / blood*
Peptide Fragments / blood
Severity of Illness Index
Ventricular Function, Left
Vitamin D / blood
Vitamin D Deficiency / blood, complications*, diagnosis
|0/ADIPOQ protein, human; 0/Adiponectin; 0/Biological Markers; 0/PTH protein, human; 0/Parathyroid Hormone; 0/Peptide Fragments; 0/glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; 1406-16-2/Vitamin D; 9007-34-5/Collagen|
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