Document Detail

Parathyroid hormone-related protein as a potential tumor marker: a case report of ovarian clear cell carcinoma.
MedLine Citation:
PMID:  16445533     Owner:  NLM     Status:  MEDLINE    
Hypercalcemia is one of the important paraneoplastic syndromes, mostly occurring in patients with advanced cancer. Clear cell carcinoma is known to be one of the most common histological subtypes of ovarian tumor associated with hypercalcemia. We present a case of ovarian clear cell carcinoma with hypercalcemia caused by elevated serum parathyroid hormone-related protein (PTHrP). PTHrP mRNA and protein were detected by reverse transcription-polymerase chain reaction and immunohistochemical analysis in the primary and metastasis lesions. Serum calcium and PTHrP levels returned to normal after antihypercalcemic treatment and a radical operation, but they elevated along with the recurrence. Because tumor markers such as carcinoembryonic antigen, carbohydrate antigen (CA)125 and CA19-9 were unstable owing to the patient's liver cirrhosis and were not reliable data for management, serum calcium and PTHrP levels are shown to have been a potential indicator of the recurrence in this case.
Naoko Suwaki; Hisashi Masuyama; Yasushi Mizutani; Junichi Kodama; Yuji Hiramatsu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  32     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-31     Completed Date:  2006-05-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  94-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Okayama University Medical School, Okayama, Japan.
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MeSH Terms
Adenocarcinoma, Clear Cell / diagnosis*,  therapy
Hypercalcemia / etiology*,  therapy
Middle Aged
Ovarian Neoplasms / diagnosis*,  therapy
Parathyroid Hormone-Related Protein / blood*
Retroperitoneal Neoplasms / secondary
Splenic Neoplasms / secondary
Tumor Markers, Biological / blood*
Reg. No./Substance:
0/Parathyroid Hormone-Related Protein; 0/Tumor Markers, Biological

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