Document Detail


Parathyroid hormone-related protein antigen localization distinguishes between mesothelioma and adenocarcinoma of the lung.
MedLine Citation:
PMID:  7636626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The distinction between pleural malignant mesothelioma and pulmonary adenocarcinoma remains a problem in diagnostic histopathology. Parathyroid hormone-related protein (PTHrP) has been demonstrated in the neoplastic cells of malignant mesotheliomata, using a polyclonal antiserum raised to synthetic PTHrP(1-16). In a series of 44 malignant mesotheliomata and 44 cases of pleural adenocarcinomata, PTHrP was localized immunohistochemically in 84 per cent of the mesotheliomata and in 11 per cent of the pleural adenocarcinomata. Normal and reactive mesothelium did not contain detectable PTHrP. The presence of PTHrP in a very high percentage of malignant mesotheliomata indicates the value of including it in the panel of antibodies utilized in the differential diagnosis of mesothelioma.
Authors:
S P Clark; S T Chou; T J Martin; J A Danks
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pathology     Volume:  176     ISSN:  0022-3417     ISO Abbreviation:  J. Pathol.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-09-13     Completed Date:  1995-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  161-5     Citation Subset:  IM    
Affiliation:
St Vincent's Institute of Medical Research, Fitzroy, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / diagnosis*
Adult
Aged
Aged, 80 and over
Diagnosis, Differential
Humans
Immunohistochemistry
Lung Neoplasms / diagnosis*
Mesothelioma / diagnosis*
Middle Aged
Neoplasm Proteins / analysis*
Parathyroid Hormone / analysis*
Parathyroid Hormone-Related Protein
Pleural Neoplasms / diagnosis
Proteins / analysis*
Tumor Markers, Biological / analysis*
Chemical
Reg. No./Substance:
0/Neoplasm Proteins; 0/PTHLH protein, human; 0/Parathyroid Hormone; 0/Parathyroid Hormone-Related Protein; 0/Proteins; 0/Tumor Markers, Biological

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