Document Detail

Parathyroid hormone-related protein (PTHrP) concentrations in human amniotic fluid during gestation and at the time of labour.
MedLine Citation:
PMID:  8743156     Owner:  NLM     Status:  MEDLINE    
To establish the changes associated with gestational age and labour status in parathyroid hormone-related protein (PTHrP) concentrations in the amniotic fluid, human amniotic fluid was collected from non-labouring and labouring women at < 37 weeks of gestation (preterm) and at term (> or = 37 weeks). PTHrP was assayed by a specific N-terminal radioimmunoassay. PTHrP concentrations in amniotic fluid obtained from non-labouring women were significantly lower at preterm (15-36 weeks; 14.1 +/- 2.5 pmol L(-1); n = 11) than at term (37-42 weeks; 39.3 +/- 7.6 pmol L(-1); n = 16; P < 0.0009). Concentrations of PTHrP in amniotic fluid obtained from labouring women were also significantly lower at preterm (27-36 week; 12.2 +/- 4.7 pmol L(-1); n = 4; P < 0.01) than at term (37-42 weeks; 63. 8 +/- 19.6 pmol L(-1); n = 9). There were no significant changes in concentration associated with labour status, either at preterm or at term. The physiological significance of elevated amniotic fluid concentrations of PTHrP has yet to be established, but the data are consistent with the suggestion that PTHrP plays a role in fetal membrane function during late gestation.
M E Wlodek; P W Ho; G E Rice; J M Moseley; T J Martin; S P Brennecke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproduction, fertility, and development     Volume:  7     ISSN:  1031-3613     ISO Abbreviation:  Reprod. Fertil. Dev.     Publication Date:  1995  
Date Detail:
Created Date:  1996-09-13     Completed Date:  1996-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8907465     Medline TA:  Reprod Fertil Dev     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  1509-13     Citation Subset:  IM    
Department of Perinatal Medicine, Royal Women's Hospital, Carlton, Vic., Australia.
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MeSH Terms
Amniotic Fluid / metabolism*
Labor, Obstetric / metabolism*
Parathyroid Hormone-Related Protein
Pregnancy / metabolism*
Proteins / metabolism*
Time Factors
Reg. No./Substance:
0/PTHLH protein, human; 0/Parathyroid Hormone-Related Protein; 0/Proteins

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