Document Detail


Parathyroid hormone-related peptide and the parathyroid hormone/parathyroid hormone-related peptide receptor in skeletal development.
MedLine Citation:
PMID:  9263678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Parathyroid hormone-related peptide has recently been shown to have important functions in the control of cellular growth and differentiation. Studies using knockout and transgenic technology have played a key part in the development of our understanding of its physiological role in endochondral bone development and adult skeletal homeostasis. Acting, at least partly, through the parathyroid hormone/parathyroid hormone-related peptide receptor, parathyroid hormone-related peptide profoundly influences chondrocytic and osteogenic cell biology. Further understanding of these functions may have important implications in the pathophysiology and treatment of human skeletal disorders, including osteoporosis.
Authors:
A C Karaplis; L Vautour
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  6     ISSN:  1062-4821     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-29     Completed Date:  1997-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  308-13     Citation Subset:  IM; S    
Affiliation:
Department of Medicine, McGill University, Montreal, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Apoptosis
Bone Development / physiology*
Bone Diseases, Metabolic / etiology,  metabolism
Bone Remodeling / physiology
Cartilage / cytology,  metabolism
Cell Differentiation
Hedgehog Proteins
Humans
Mice
Mice, Knockout
Osteoblasts / metabolism
Osteoporosis / drug therapy
Parathyroid Hormone-Related Protein
Proteins / genetics,  metabolism*,  therapeutic use
Receptor, Parathyroid Hormone, Type 1
Receptors, Parathyroid Hormone / metabolism*
Trans-Activators*
Chemical
Reg. No./Substance:
0/Hedgehog Proteins; 0/PTHLH protein, human; 0/Parathyroid Hormone-Related Protein; 0/Proteins; 0/Receptor, Parathyroid Hormone, Type 1; 0/Receptors, Parathyroid Hormone; 0/Trans-Activators

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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