| Parathyroid hormone-related peptide may increase mammary blood flow. | |
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MedLine Citation:
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PMID: 8304054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amino-terminal fragments of PTHrP were previously shown to increase regional blood flow in laboratory animals. Since PTHrP is produced in the lactating mammary gland and associated nutrient vessels, we examined the effects of peptide fragments of PTHrP on the hemodynamics of the mammary gland of dried sheep. The left arterial mammary blood flow measured using ultrasonic flow probes in four dried Lacaune ewes was 233 +/- 11 ml/minute. It was significantly increased when synthetic human PTHrP-(1-34) or (1-86) fragments were injected into the mammary artery. The effect was dose dependent for PTHrP-(1-34), varying between 0.0075 and 0.3 nmol/kg body weight. PTHrP-(140-173) fragment lacked any vasorelaxant activity. Synthetic human endothelin (ET1) decreased arterial blood flow in a dose-dependent manner. This decrease was inhibited by PTHrP-(1-34), and this inhibition was PTHrP dose related. When ET1 (10 pmol/kg body weight) was injected together with PTHrP-(1-86) (100 pmol/kg body weight), only a significant increase in mammary blood flow was observed. Thus, PTHrP produced by the lactating mammary gland may be involved in the regulation of mammary blood flow. |
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Authors:
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M J Davicco; J Rouffet; D Durand; J Lefaivre; J P Barlet |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Volume: 8 ISSN: 0884-0431 ISO Abbreviation: J. Bone Miner. Res. Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-03-08 Completed Date: 1994-03-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8610640 Medline TA: J Bone Miner Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1519-24 Citation Subset: IM |
Affiliation:
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INRA Clermont Fd-Theix, Ceyrat, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / drug effects Dose-Response Relationship, Drug Endothelins / pharmacology Female Heart Rate / drug effects Humans Mammary Glands, Animal / blood supply* Parathyroid Hormone / pharmacology* Parathyroid Hormone-Related Protein* Peptide Fragments / pharmacology* Peptides / pharmacology* Proteins / pharmacology* Recombinant Proteins / pharmacology Regional Blood Flow / drug effects Sheep |
| Chemical | |
Reg. No./Substance:
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0/Endothelins; 0/Parathyroid Hormone; 0/Parathyroid Hormone-Related Protein; 0/Peptide Fragments; 0/Peptides; 0/Proteins; 0/Recombinant Proteins; 0/parathyroid hormone-related protein (1-86); 112540-82-6/parathyroid hormone-related protein (1-34) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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