Document Detail


Parathyroid hormone, platelet calcium, and blood pressure in normotensive subjects.
MedLine Citation:
PMID:  1885225     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Relations between platelet cytosolic calcium, parathyroid hormone, and blood pressure were investigated in 91 normotensive subjects: 47 men and 44 women ranging in age from 24 to 70 years. The men had higher mean arterial blood pressure, serum creatinine, and body mass index than the women. Serum total calcium, plasma ionized calcium, and parathyroid hormone (measured as both intact hormone and mid-molecule fragment) were not different between men and women; however, serum phosphate was higher in women than in men. Basal platelet cytosolic calcium was higher in men than in women (113.7 +/- 1.9 versus 105.9 +/- 1.7, respectively; p less than 0.01), but there was no difference in the peak platelet cytosolic calcium responses to thrombin between the two groups. In the combined group of male and female subjects, platelet cytosolic calcium correlated with diastolic blood pressure and mean arterial pressure (r = 0.37, p less than 0.001 and r = 0.32, p less than 0.01, respectively). Intact parathyroid hormone correlated with systolic and mean arterial blood pressure (r = 0.41, p less than 0.001 for both). Age correlated with both systolic blood pressure (r = 0.40, p less than 0.001) and intact parathyroid hormone (r = 0.51, p less than 0.001). When multiple regression analysis was performed using mean arterial pressure as the dependent variable, platelet cytosolic calcium and intact parathyroid hormone maintained significant correlations with mean arterial pressure. Platelet cytosolic calcium did not correlate with intact parathyroid hormone. These results suggest that both platelet cytosolic calcium and intact parathyroid hormone are associated with blood pressure regulation in normotensive subjects. However, the influences of these two factors on blood pressure are not interrelated.
Authors:
A Brickman; M Nyby; K von Hungen; P Eggena; M Tuck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  18     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-10-08     Completed Date:  1991-10-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  176-82     Citation Subset:  IM    
Affiliation:
Division of Endocrinology, Sepulveda Veterans Administration Medical Center, CA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Blood Platelets / chemistry*
Blood Pressure*
Body Mass Index
Calcium / blood*
Creatinine / blood
Female
Humans
Male
Middle Aged
Multivariate Analysis
Parathyroid Hormone / blood*
Phosphates / blood
Regression Analysis
Sex Factors
Chemical
Reg. No./Substance:
0/Parathyroid Hormone; 0/Phosphates; 60-27-5/Creatinine; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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