Document Detail

Parathyroid hormone-mediated incorporation of 32P-orthophosphate into phosphatidic acid and phosphatidylinositol in renal cortical slices.
MedLine Citation:
PMID:  188626     Owner:  NLM     Status:  MEDLINE    
Parathyroid hormone increased the incorporation of Na2H32PO4 into phosphatidic acid and phosphatidylinositol in cat renal cortical slices. Incorporation was not observed into any other phospholipid. The effects were seen as early as one minute for phosphatidic acid and ten minutes for phosphatidylinositol. 8-Bromoadnosine 3',5'-monophosphate did not mimic the effects of parathyroid hormone. Concentrations of parathyroid hormone, 1 x 10(-8)M to 1 x 10(-7)M, which increased the incorporation of 32p into phosphatidic acid and phosphatidylinositol maximally, did not alter tissue cyclic AMP levels suggesting that the incorporation of 32p was independent of cyclic AMP.
H Lo; D C Lehotay; D Katz; G S Levey
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrine research communications     Volume:  3     ISSN:  0093-6391     ISO Abbreviation:  Endocr Res Commun     Publication Date:  1976  
Date Detail:
Created Date:  1977-03-31     Completed Date:  1977-03-31     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0426337     Medline TA:  Endocr Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  377-85     Citation Subset:  IM    
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MeSH Terms
Cyclic AMP / analogs & derivatives,  metabolism,  pharmacology
Dose-Response Relationship, Drug
Kidney Cortex / metabolism*
Organ Specificity / drug effects
Parathyroid Hormone / pharmacology*
Phosphates / metabolism*
Phosphatidic Acids / biosynthesis*
Phosphatidylinositols / biosynthesis*
Phosphorus Radioisotopes
Time Factors
Reg. No./Substance:
0/Parathyroid Hormone; 0/Phosphates; 0/Phosphatidic Acids; 0/Phosphatidylinositols; 0/Phosphorus Radioisotopes; 60-92-4/Cyclic AMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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