| Parathyroid hormone and genetic hypertension. | |
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MedLine Citation:
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PMID: 1612792 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent research provides evidence that parathyroid hormone is implicated in the pathogenesis of genetic hypertension. Abnormalities in calcium metabolism in genetic hypertension have been reported. These include hypercalciuria, depressed serum ionized calcium associated with enhanced serum parathyroid hormone levels. Calcium supplement resulted in normalization of calcium metabolism and reduction in blood pressure. In addition, removal of parathyroid glands attenuated the rise in blood pressure in genetic hypertensive rat. This review focuses on the links between calcium metabolism and calcium endocrine system abnormalities and the etiology of experimental genetic hypertension. The mechanisms by which dietary supplement and parathyroidectomy lower genetic hypertension are also discussed. Although the causality of raised parathyroid hormone in genetic hypertension is not yet fully understood, we conclude that this hormone may play a permissive effect in the development of hypertension. |
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Authors:
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R Schleiffer |
Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: International journal of cardiology Volume: 35 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 1992 Jun |
Date Detail:
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Created Date: 1992-07-30 Completed Date: 1992-07-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 303-10 Citation Subset: IM |
Affiliation:
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Biologie Cellulaire & Physiopathologie Digestives, INSERM U61, Strasbourg, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Blood Pressure / drug effects Calcium / metabolism Calcium, Dietary / pharmacology Homeostasis Humans Hypertension / etiology, genetics*, metabolism Mice Mice, Inbred Strains Parathyroid Hormone / pharmacology, physiology* Parathyroidectomy Rats Rats, Inbred SHR Rats, Inbred WKY |
| Chemical | |
Reg. No./Substance:
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0/Calcium, Dietary; 0/Parathyroid Hormone; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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