Document Detail

Parathyroid hormone and genetic hypertension.
MedLine Citation:
PMID:  1612792     Owner:  NLM     Status:  MEDLINE    
Recent research provides evidence that parathyroid hormone is implicated in the pathogenesis of genetic hypertension. Abnormalities in calcium metabolism in genetic hypertension have been reported. These include hypercalciuria, depressed serum ionized calcium associated with enhanced serum parathyroid hormone levels. Calcium supplement resulted in normalization of calcium metabolism and reduction in blood pressure. In addition, removal of parathyroid glands attenuated the rise in blood pressure in genetic hypertensive rat. This review focuses on the links between calcium metabolism and calcium endocrine system abnormalities and the etiology of experimental genetic hypertension. The mechanisms by which dietary supplement and parathyroidectomy lower genetic hypertension are also discussed. Although the causality of raised parathyroid hormone in genetic hypertension is not yet fully understood, we conclude that this hormone may play a permissive effect in the development of hypertension.
R Schleiffer
Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  International journal of cardiology     Volume:  35     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-30     Completed Date:  1992-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  303-10     Citation Subset:  IM    
Biologie Cellulaire & Physiopathologie Digestives, INSERM U61, Strasbourg, France.
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MeSH Terms
Age Factors
Blood Pressure / drug effects
Calcium / metabolism
Calcium, Dietary / pharmacology
Hypertension / etiology,  genetics*,  metabolism
Mice, Inbred Strains
Parathyroid Hormone / pharmacology,  physiology*
Rats, Inbred SHR
Rats, Inbred WKY
Reg. No./Substance:
0/Calcium, Dietary; 0/Parathyroid Hormone; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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