Document Detail


Parathyroid gland carcinoma in a Wistar rat.
MedLine Citation:
PMID:  12637761     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An anaplastic carcinoma was found in one of the two parathyroids of a 2-year-old male Wistar rat, which was sacrificed at the end of a carcinogenicity study. Morphologically, it was characterized by the presence of nodular areas of pleomorphic and dense cells with numerous atypical mitoses and large regions of smaller and dark monomorphic cells devoid of mitoses and forming small cystic spaces. Local invasion of the capsule and pronounced compression of the parenchyma of the thyroid gland were observed. Immunohistochemically, the tumor was markedly positive for the parathyroid hormone and negative for the thyroid transcription factor. The proliferative activity was assessed by immunostaining the endogenous cell proliferation associated-antigen Ki-67, and the proliferating cell nuclear antigen. The diagnosis of carcinoma of the parathyroid was made on the basis of microscopic and immunohistochemical findings.
Authors:
V Pace; S Scarsella; E Perentes
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Veterinary pathology     Volume:  40     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-14     Completed Date:  2003-06-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-6     Citation Subset:  IM    
Affiliation:
Dompè SpA, R & D, L'Aquila, Italy. virgilio.pace@dompe.it.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma / metabolism,  pathology,  veterinary*
Immunohistochemistry / veterinary
Ki-67 Antigen / metabolism
Male
Nuclear Proteins / metabolism
Parathyroid Hormone / metabolism
Parathyroid Neoplasms / metabolism,  pathology,  veterinary*
Proliferating Cell Nuclear Antigen / metabolism
Rats
Rats, Wistar
Transcription Factors / metabolism
Chemical
Reg. No./Substance:
0/Ki-67 Antigen; 0/Nuclear Proteins; 0/Parathyroid Hormone; 0/Proliferating Cell Nuclear Antigen; 0/Transcription Factors; 0/thyroid nuclear factor 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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