| Parathyroid gland carcinoma in a Wistar rat. | |
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MedLine Citation:
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PMID: 12637761 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An anaplastic carcinoma was found in one of the two parathyroids of a 2-year-old male Wistar rat, which was sacrificed at the end of a carcinogenicity study. Morphologically, it was characterized by the presence of nodular areas of pleomorphic and dense cells with numerous atypical mitoses and large regions of smaller and dark monomorphic cells devoid of mitoses and forming small cystic spaces. Local invasion of the capsule and pronounced compression of the parenchyma of the thyroid gland were observed. Immunohistochemically, the tumor was markedly positive for the parathyroid hormone and negative for the thyroid transcription factor. The proliferative activity was assessed by immunostaining the endogenous cell proliferation associated-antigen Ki-67, and the proliferating cell nuclear antigen. The diagnosis of carcinoma of the parathyroid was made on the basis of microscopic and immunohistochemical findings. |
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Authors:
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V Pace; S Scarsella; E Perentes |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Veterinary pathology Volume: 40 ISSN: 0300-9858 ISO Abbreviation: Vet. Pathol. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-14 Completed Date: 2003-06-19 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0312020 Medline TA: Vet Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 203-6 Citation Subset: IM |
Affiliation:
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Dompè SpA, R & D, L'Aquila, Italy. virgilio.pace@dompe.it. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma / metabolism, pathology, veterinary* Immunohistochemistry / veterinary Ki-67 Antigen / metabolism Male Nuclear Proteins / metabolism Parathyroid Hormone / metabolism Parathyroid Neoplasms / metabolism, pathology, veterinary* Proliferating Cell Nuclear Antigen / metabolism Rats Rats, Wistar Transcription Factors / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Ki-67 Antigen; 0/Nuclear Proteins; 0/Parathyroid Hormone; 0/Proliferating Cell Nuclear Antigen; 0/Transcription Factors; 0/thyroid nuclear factor 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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