Document Detail

Parathyroid cell number and size in hypocalcemic young rats.
MedLine Citation:
PMID:  1772646     Owner:  NLM     Status:  MEDLINE    
Weanling rats were fed diets with normal (1%) or low (0.08% or 0.02%, respectively) Ca content for 28 days prior to sacrifice. The total volume of the parathyroids was estimated from serial sections. Volume density of secretory cells was calculated according to conventional stereological techniques, whereas cell number and cell size were estimated by the dissector method. Compared with controls the animals of the experimental groups developed moderate and severe hypocalcemia and their parathyroids were enlarged with a proportional growth of parenchyma and interstitium. Related to the body weight, secretory cell volume was highest in animals with severe hypocalcemia. In the enlarged glands the size of parathyroid secretory cells was increased by 30-40%, whereas total cell number was unaltered. Thus, the increased parathyroid size was due to cell hypertrophy rather than hyperplasia.
A Wernerson; S M Widholm; O Svensson; F P Reinholt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  99     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-02-28     Completed Date:  1992-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1096-102     Citation Subset:  IM    
Department of Pathology, Karolinska Institutet, Huddinge University Hospital, Sweden.
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MeSH Terms
Calcitriol / physiology
Cell Count
Hypocalcemia / pathology*
Parathyroid Glands / pathology*
Parathyroid Hormone / biosynthesis
Rats, Inbred Strains
Reg. No./Substance:
0/Parathyroid Hormone; 32222-06-3/Calcitriol

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