Document Detail

Parathyroid hormone-related protein in preterm human milk.
MedLine Citation:
PMID:  19772375     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Parathyroid hormone-related protein (PTHrP) has the ability to activate parathyroid hormone receptors and cause hypercalcemia. High concentrations of PTHrP are found in human breastmilk of mothers of term-infants. It is not known whether PTHrP is excreted in preterm human milk. This study tested the hypothesis that PTHrP concentrations in milk obtained from mothers of preterm infants are similar to those found in milk from mothers of term infants. METHODS: We collected samples of expressed human milk obtained from 27 mothers of preterm infants (27-34 weeks' gestation) and from 16 mothers of full-term infants. Samples were collected within the first 72 hours postpartum (colostrum) and again at 1 and 2 weeks postpartum. PTHrP concentrations in these samples were measured by two-site immunoradiometric assay. RESULTS: PTHrP concentrations were significantly higher in samples obtained after 1 week postpartum than in samples obtained during the first 72 hours of life in breastmilk obtained from mothers of both term and preterm infants (P < 0.0001). PTHrP concentrations were similar in colostrum and after 1 week in term and preterm milk. PTHrP concentrations after 2 weeks of lactation were significantly higher in samples obtained from mothers of term infants (P < 0.006). CONCLUSION: Human milk expressed by mothers of preterm infants contains amounts of PTHrP similar to those measured in milk expressed by mothers of term infants.
Ronit Lubetzky; Yosef Weisman; Shaul Dollberg; Lea Herman; Dror Mandel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine     Volume:  5     ISSN:  1556-8342     ISO Abbreviation:  Breastfeed Med     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-09     Completed Date:  2010-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101260777     Medline TA:  Breastfeed Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  67-9     Citation Subset:  IM    
Department of Neonatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
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MeSH Terms
Case-Control Studies
Colostrum / chemistry
Gestational Age
Infant, Newborn
Infant, Premature*
Lactation / metabolism*
Milk, Human / chemistry*
Parathyroid Hormone-Related Protein / analysis*
Postpartum Period
Time Factors
Reg. No./Substance:
0/Parathyroid Hormone-Related Protein

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