| Parasympathetic tonic dilatory influences on cerebral vessels. | |
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MedLine Citation:
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PMID: 19195933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Parasympathetic nerves from the pterygopalatine ganglia may participate in development of cluster headaches, in vascular responses to hypertension and in modulation of damage due to stroke. Stimulation of the nerves elicits cerebral vasodilatation, but it is not known if the nerves tonically influence cerebrovascular tone. We hypothesized that parasympathetics provide a tonic vasodilator influence and tested that hypothesis by measuring cerebral blood flow in anesthetized rats before and after removal of a pterygopalatine ganglion. Ganglion removal led to reduced cerebral blood flow without changing blood pressure. Thus, parasympathetic nerves provide tonic vasodilatory input to cerebral blood vessels. |
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Authors:
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Nicholas C Boysen; Deidre Nitschke Dragon; William T Talman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-02-05 |
Journal Detail:
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Title: Autonomic neuroscience : basic & clinical Volume: 147 ISSN: 1872-7484 ISO Abbreviation: Auton Neurosci Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-21 Completed Date: 2009-06-26 Revised Date: 2011-04-07 |
Medline Journal Info:
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Nlm Unique ID: 100909359 Medline TA: Auton Neurosci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 101-4 Citation Subset: IM |
Affiliation:
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Laboratory of Neurobiology, University of Iowa, Iowa City, IA 52242, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autonomic Pathways / anatomy & histology, physiology Cerebral Arteries / innervation*, physiology* Cerebrovascular Circulation / physiology* Denervation Facial Nerve / anatomy & histology, physiology Ganglia, Parasympathetic / anatomy & histology, physiology, surgery Male Parasympathetic Nervous System / anatomy & histology, physiology* Rats Rats, Sprague-Dawley Species Specificity Vasodilation / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL059593-08/HL/NHLBI NIH HHS; R01 HL59593/HL/NHLBI NIH HHS |
| Comments/Corrections | |
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