| Parasites paralyze cellular host defense system to promote virulence. | |
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MedLine Citation:
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PMID: 21147459 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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To promote their survival, intracellular pathogens must confront microbicidal activities induced by interferons. In this issue of Cell Host & Microbe, Fentress et al. show that Toxoplasma gondii evades intracellular killing by deploying a virulence determinant, ROP18, which acts by directly phosphorylating and disabling an IFN-γ-inducible immunity-related GTPase involved in pathogen clearance. |
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Authors:
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Carl G Feng; Alan Sher |
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Publication Detail:
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Type: Comment; Journal Article; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: Cell host & microbe Volume: 8 ISSN: 1934-6069 ISO Abbreviation: Cell Host Microbe Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-14 Completed Date: 2011-04-06 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 101302316 Medline TA: Cell Host Microbe Country: United States |
Other Details:
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Languages: eng Pagination: 463-4 Citation Subset: - |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. cfeng@niaid.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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Z01 AI000579-19/AI/NIAID NIH HHS |
| Comments/Corrections | |
Comment On:
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Cell Host Microbe. 2010 Dec 16;8(6):484-95
[PMID:
21147463
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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