Document Detail


Parasite histories and novel phylogenetic tools: alternative approaches to inferring parasite evolution from molecular markers.
MedLine Citation:
PMID:  16387305     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Parasitological research is often contingent on the knowledge of the phylogeny/genealogy of the studied group. Although molecular phylogenetics has proved to be a powerful tool in such investigations, its application in the traditional fashion, based on a tree inference from the primary nucleotide sequences may, in many cases, be insufficient or even improper. These limitations are due to a number of factors, such as a scarcity/ambiguity of phylogenetic information in the sequences, an intricacy of gene relationships at low phylogenetic levels, or a lack of criteria when deciding among several competing coevolutionary scenarios. With respect to the importance of a precise and reliable phylogenetic background in many biological studies, attempts are being made to extend molecular phylogenetics with a variety of new data sources and methodologies. In this review, selected approaches potentially applicable to parasitological research are presented and their advantages as well as drawbacks are discussed. These issues include the usage of idiosyncratic markers (unique features with presumably low probability of homoplasy), such as insertion of mobile elements, gene rearrangements and secondary structure features; the problem of ancestral polymorphism and reticulate relationships at low phylogenetic levels; and the utility of a molecular clock to facilitate discrimination among alternative scenarios in host-parasite coevolution.
Authors:
Václav Hypsa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2005-11-28
Journal Detail:
Title:  International journal for parasitology     Volume:  36     ISSN:  0020-7519     ISO Abbreviation:  Int. J. Parasitol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-13     Completed Date:  2006-10-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0314024     Medline TA:  Int J Parasitol     Country:  England    
Other Details:
Languages:  eng     Pagination:  141-55     Citation Subset:  IM    
Affiliation:
Faculty of Biological Sciences, University of South Bohemia, and Institute of Parasitology, Academy of Sciences of the Czech Republic, Branisovská 31, 37005 Ceské Budejovice, Czech Republic. vacatko@paru.cas.cz
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MeSH Terms
Descriptor/Qualifier:
Animals
Evolution*
Genes, Protozoan*
Genetic Markers
Host-Parasite Interactions
Parasites / genetics*
Phylogeny*
Species Specificity
Chemical
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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