Document Detail


Paraoxonase2 C311S polymorphism and low levels of HDL contribute to a higher mortality risk after acute myocardial infarction in elderly patients.
MedLine Citation:
PMID:  19540141     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is well known that oxidative stress plays an important role in atherosclerosis and age-related diseases. The antioxidant properties of the Human Paraoxonase gene family (PON1, 2, 3) have been widely investigated, as well as a possible role of the such gene family in cardiovascular disease. In this study, we investigated the relationship between the C311S PON2 polymorphism and the prognosis of acute myocardial infarction (AMI). We analyzed the PON2 C311S polymorphism in 442 elderly patients who had experienced an AMI. PON2 C311S genotypes were identified by PCR based analysis and analyzed as C- (SS genotype) or C+ (CS+CC) carriers. After 1 year of follow-up, the cardiovascular mortality rate in a sub-group of 295 AMI patients was calculated. We found that AMI patients carrying CS+CC genotypes (C+ carriers) had a history of type 2 diabetes mellitus, low levels of HDL-cholesterol and higher levels of TroponinT (TnT). Furthermore, we found that C+ carrier patients with low levels of HDL-cholesterol had an increased risk for mortality after 1 year of follow-up (Log Rank=11.45, p=0.001). Our study suggests a possible role for PON2 C311S polymorphism in the pathogenesis of cardiac ischemic damage. Patients with at least one C allele (C+ carriers) represent a category of subjects at a higher risk for the development of AMI with a worse prognosis. Our findings suggest the need for a more careful clinical monitoring in older persons with such characteristics.
Authors:
Francesca Marchegiani; Liana Spazzafumo; Mauro Provinciali; Maurizio Cardelli; Fabiola Olivieri; Claudio Franceschi; Fabrizia Lattanzio; Roberto Antonicelli
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-27
Journal Detail:
Title:  Molecular genetics and metabolism     Volume:  98     ISSN:  1096-7206     ISO Abbreviation:  Mol. Genet. Metab.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-13     Completed Date:  2010-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9805456     Medline TA:  Mol Genet Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  314-8     Citation Subset:  IM    
Affiliation:
Immunology Center, Italian National Research Center on Aging (I.N.R.C.A.), Ancona, Italy. fr.marchegiani@inrca.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aryldialkylphosphatase / genetics*
Cholesterol, HDL / blood*
Female
Genotype
Humans
Male
Myocardial Infarction / epidemiology,  genetics*,  mortality*
Polymorphism, Genetic*
Risk Factors
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; EC 3.1.8.1/Aryldialkylphosphatase; EC 3.1.8.1/PON2 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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