Document Detail


Paraoxonase gene polymorphism in Japanese subjects with coronary heart disease.
MedLine Citation:
PMID:  8960946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the association of paraoxonase (PON) gene polymorphism with both the occurrence of coronary heart disease (CHD) and the severity of coronary artery stenosis in Japanese subjects. PON is a protein associated with plasma HDL. It has been hypothesized an A/B (Gln 192-->Arg) polymorphism of PON may be involved in the pathogenesis of CHD, especially among subjects with non-insulin-dependent diabetes mellitus (NIDDM). The polymorphism was determined in 134 patients with myocardial infarction (MI) or angina pectoris, and in 252 healthy subjects as controls. The frequencies of the AA, AB, and BB genotypes in the patients were 15, 50 and 35%, respectively, and these frequencies did not differ from those in control subjects (14, 49, and 37%). The relative risk of CHD was not found to be associated with these genotypes. These data also were similar among selected subgroups (patients with MIs, those with a low-risk lipoprotein profile for CHD, and those with NIDDM). Neither the number of affected vessels nor Gensini's scores differed among the genotype groups. Our case-control study in Japanese subjects did not show that the PON A/B polymorphism is associated with a risk of CHD.
Authors:
T Suehiro; Y Nakauchi; M Yamamoto; K Arii; H Itoh; N Hamashige; K Hashimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  57     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-11     Completed Date:  1997-03-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  69-73     Citation Subset:  IM    
Affiliation:
Second Department of Internal Medicine, Kochi Medical School, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aryldialkylphosphatase
Case-Control Studies
Constriction, Pathologic
Coronary Angiography
Coronary Disease / enzymology*
Esterases / genetics*
Female
Genotype
Humans
Japan
Male
Middle Aged
Polymorphism, Genetic*
Chemical
Reg. No./Substance:
EC 3.1.-/Esterases; EC 3.1.8.1/Aryldialkylphosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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