Document Detail


Paraoxonase and arylesterase activities in patients with cardiac syndrome X, and their relationship with oxidative stress markers.
MedLine Citation:
PMID:  17301599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Paraoxonase-1 is a high-density lipoprotein-associated enzyme with three activities, which are paraoxonase, arylesterase and dyazoxonase. Paraoxonase-1 was shown to decrease in patients with cardiovascular diseases. We aimed to examine serum paraoxonase and arylesterase activities, and their relation with oxidative stress markers such as lipid hydroperoxide and total antioxidant status in patients with cardiac syndrome X. METHODS: Forty-one consecutive patients with cardiac syndrome X (CSX group), 33 consecutive patients without cardiac syndrome X (non-cardiac syndrome X group) and 20 healthy volunteers as control group were taken into the study. Serum paraoxonase and arylesterase activities were measured spectrophotometrically. Lipid hydroperoxide levels were measured by ferrous oxidation with xylenol orange assay. Total antioxidant status was determined using an automated measurement method. RESULTS: Basal paraoxonase, salt-stimulated paraoxonase and arylesterase activities were significantly lower in patients with cardiac syndrome X than those of the non-cardiac syndrome X and control groups (P<0.001, for both). Moreover, lipid hydroperoxide was found at high level, and total antioxidant status was found at low level in patients with cardiac syndrome X than control and non-cardiac syndrome X groups (P<0.001, for all). In patients with cardiac syndrome X, in multiple linear regression analysis, both paraoxonase and arylesterase activities were independently correlated with lipid hydroperoxide levels (P=0.001, P=0.003, respectively), and also arylesterase activity was independently correlated with magnitude of ST depression (P=0.002). CONCLUSION: Reduced paraoxonase and arylesterase activities and total antioxidant status levels and enhanced lipid hydroperoxide levels in patients with cardiac syndrome X might indicate increased oxidative stress that can play a role in pathogenesis of cardiac syndrome X.
Authors:
Mustafa Gur; Ali Yildiz; Recep Demirbag; Remzi Yilmaz; Mehmet Aslan; Ibrahim Ozdogru; Ozcan Erel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  18     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-15     Completed Date:  2007-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  89-95     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Faculty of Medicine, Harran University, Sanliurfa, Turkey. drmugur@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / analysis
Aryldialkylphosphatase / blood*
Biological Markers
Carboxylic Ester Hydrolases / blood*
Coronary Angiography
Exercise Test
Female
Humans
Male
Microvascular Angina / blood*,  radiography
Middle Aged
Oxidative Stress*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; EC 3.1.1.-/Carboxylic Ester Hydrolases; EC 3.1.1.2/arylesterase; EC 3.1.8.1/Aryldialkylphosphatase

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