| Paraoxonase-1 expression is up-regulated in Down syndrome fetal liver. | |
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MedLine Citation:
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PMID: 16806076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with Down syndrome appear to be protected from the development of atherosclerosis. On the contrary, hyperhomocysteinemia is associated with an increased risk for atherosclerosis. As hyperhomocysteinemia due to cystathionine beta synthase deficiency is associated with a decreased expression of paraoxonase-1, a major anti-atherosclerotic component secreted by the liver, we aimed to analyze the expression of paraoxonase-1 and cystathionine beta synthase in Down syndrome fetal liver by quantitative real-time reverse transcriptase-polymerase chain reaction. Paraoxonase-1 was up-regulated in Down syndrome fetal liver, while cystathionine beta synthase gene expression in Down syndrome fetuses was similar to the gene level in control fetuses. Moreover, there was no evidence for an association between paraoxonase-1 genotypes influencing paraoxonase-1 gene expression and Down syndrome. Since most serum paraoxonase-1 is synthesized in the liver, an increase of hepatic paraoxonase-1 expression might be one of the factors which could explain the low incidence of atherosclerotic vascular disease in Down syndrome. |
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Authors:
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Nathalie Janel; Olivier Christophe; Emilie Aït Yahya-Graison; Julien Hamelet; Evelyne Paly; Marguerite Prieur; Anne-Lise Delezoïde; Jean Maurice Delabar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-06-16 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 346 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-07-03 Completed Date: 2006-08-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 1303-6 Citation Subset: IM |
Affiliation:
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EA 3508, Université Paris 7--Denis Diderot, Paris, France. janel@paris7.jussieu.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aryldialkylphosphatase
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genetics,
metabolism* Down Syndrome / metabolism* Fetus / anatomy & histology Gene Expression / physiology* Humans Liver / metabolism Up-Regulation |
| Chemical | |
Reg. No./Substance:
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EC 3.1.8.1/Aryldialkylphosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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