| Paraoxonase 1 activity as a predictor of cardiovascular disease in type 2 diabetes. | |
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MedLine Citation:
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PMID: 21073045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of paraoxonase 1 in cardiovascular disease complications in type 2 diabetes mellitus is not fully understood. We studied paraoxonase activity towards paraoxon in 188 non-diabetic and 140 diabetic subjects using general linear models and univariate analysis. Adjusting for age revealed a reduction in activity towards paraoxon was associated with a significant increase in risk (p = 0.023) for cardiovascular disease complications in diabetic patients. Multivariate analysis of two plasma measures of paraoxonase activity using paraoxon and diazoxon also showed reduced paraoxonase activity towards paraoxon was associated with a significant increase in risk (p = 0.045) for cardiovascular disease complications in diabetic patients. These analyses showed that a reduced paraoxonase activity towards paraoxon was associated with ethnicity. Based on multivariate analysis, subjects of Malay ethnic origin have significantly higher than expected activity (p = 0.008, compared to Indians), towards paraoxon than subjects of Chinese origin who in turn had higher than expected paraoxonase activity (p = 0.028, compared to Indians) Indian subjects. |
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Authors:
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Rozaida Poh; Sekaran Muniandy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Southeast Asian journal of tropical medicine and public health Volume: 41 ISSN: 0125-1562 ISO Abbreviation: Southeast Asian J. Trop. Med. Public Health Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-11-15 Completed Date: 2010-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0266303 Medline TA: Southeast Asian J Trop Med Public Health Country: Thailand |
Other Details:
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Languages: eng Pagination: 1231-46 Citation Subset: IM |
Affiliation:
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Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. rozaiday@um.edu.my |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Aryldialkylphosphatase / blood* Biological Markers / blood Blood Glucose / analysis Cardiovascular Diseases / enzymology* Diabetes Complications / enzymology* Female Humans Linear Models Lipids / blood Malaysia Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Glucose; 0/Lipids; EC 3.1.8.1/Aryldialkylphosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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