Document Detail

Paraneoplastic vitelliform retinopathy associated with cutaneous or uveal melanoma and metastases.
MedLine Citation:
PMID:  16308825     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To report unusual vitelliform fundus findings in three cases of paraneoplastic retinopathy associated with metastasised cutaneous or uveal melanoma and in one case, a unique immunoreactivity response.
PATIENTS AND METHODS: Observational case series. The histories of three patients with MAR-like paraneoplastic retinopathy were reviewed. Electroretinography, Goldmann perimetry, fluorescein angiography, and in one case optical coherence tomography, immunohistochemistry and Western blotting were performed.
RESULTS: All patients revealed similar paraneoplastic vitelliform retinal abnormalities. Symptoms in two cases differed from the classical MAR syndrome. In one case, western blotting and immunohistochemistry demonstrated antibodies against 120-kDa, a soluble photoreceptor protein. No immunoreactivity to retinal bipolar cells was detected.
CONCLUSION: The clinical, electrophysiological, and immunological findings in our patients suggest a melanoma associated paraneoplastic origin, like in MAR syndrome. However contrary to MAR syndrome, this paraneoplastic vitelliform retinopathy exhibits a peculiar fundus picture, consisting of serous macular detachment and nummular vitelliform lesions in the posterior pole. This could be an unusual presentation of MAR or a separate paraneoplastic entity.
M Sotodeh; D Paridaens; J Keunen; M van Schooneveld; G Adamus; S Baarsma
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Klinische Monatsblätter für Augenheilkunde     Volume:  222     ISSN:  0023-2165     ISO Abbreviation:  Klin Monbl Augenheilkd     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-25     Completed Date:  2006-01-23     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  0014133     Medline TA:  Klin Monbl Augenheilkd     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  910-4     Citation Subset:  IM    
Rotterdam Eye Hospital, Department of Medical Retina and Uveitis, Rotterdam, Netherlands.
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MeSH Terms
Melanoma / pathology*,  secondary*
Middle Aged
Paraneoplastic Syndromes / pathology*
Retinal Degeneration / pathology*
Skin Neoplasms / pathology*
Uveal Neoplasms / pathology*,  secondary*
Grant Support

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