| Paraneoplastic vitelliform retinopathy associated with cutaneous or uveal melanoma and metastases. | |
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MedLine Citation:
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PMID: 16308825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To report unusual vitelliform fundus findings in three cases of paraneoplastic retinopathy associated with metastasised cutaneous or uveal melanoma and in one case, a unique immunoreactivity response. PATIENTS AND METHODS: Observational case series. The histories of three patients with MAR-like paraneoplastic retinopathy were reviewed. Electroretinography, Goldmann perimetry, fluorescein angiography, and in one case optical coherence tomography, immunohistochemistry and Western blotting were performed. RESULTS: All patients revealed similar paraneoplastic vitelliform retinal abnormalities. Symptoms in two cases differed from the classical MAR syndrome. In one case, western blotting and immunohistochemistry demonstrated antibodies against 120-kDa, a soluble photoreceptor protein. No immunoreactivity to retinal bipolar cells was detected. CONCLUSION: The clinical, electrophysiological, and immunological findings in our patients suggest a melanoma associated paraneoplastic origin, like in MAR syndrome. However contrary to MAR syndrome, this paraneoplastic vitelliform retinopathy exhibits a peculiar fundus picture, consisting of serous macular detachment and nummular vitelliform lesions in the posterior pole. This could be an unusual presentation of MAR or a separate paraneoplastic entity. |
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Authors:
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M Sotodeh; D Paridaens; J Keunen; M van Schooneveld; G Adamus; S Baarsma |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Klinische Monatsblätter für Augenheilkunde Volume: 222 ISSN: 0023-2165 ISO Abbreviation: Klin Monbl Augenheilkd Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-25 Completed Date: 2006-01-23 Revised Date: 2012-10-19 |
Medline Journal Info:
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Nlm Unique ID: 0014133 Medline TA: Klin Monbl Augenheilkd Country: Germany |
Other Details:
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Languages: eng Pagination: 910-4 Citation Subset: IM |
Affiliation:
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Rotterdam Eye Hospital, Department of Medical Retina and Uveitis, Rotterdam, Netherlands. M.Sotodeh@Lumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Male Melanoma / pathology*, secondary* Middle Aged Paraneoplastic Syndromes / pathology* Retinal Degeneration / pathology* Skin Neoplasms / pathology* Uveal Neoplasms / pathology*, secondary* |
| Grant Support | |
ID/Acronym/Agency:
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EY13053/EY/NEI NIH HHS; R01 EY013053/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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