Document Detail

Paraneoplastic thrombocytosis-induced systemic thromboembolism in a cat.
MedLine Citation:
PMID:  10580907     Owner:  NLM     Status:  MEDLINE    
A six-year-old cat presented with clinical signs consistent with distal aortic thromboembolism while clinical signs of cardiovascular disease were absent. Diagnostics, including thoracic radiographs, electrocardiography, and echocardiography revealed no cardiovascular anomalies. Thoracic radiographs revealed multifocal pulmonary lesions consistent with neoplasia. Complete blood cell count demonstrated a marked thrombocytosis, leukopenia, and neutropenia. Histopathology of the pulmonary lesions confirmed multiple bronchoalveolar carcinomas. Myelodysplasia with megakaryocytic hyperplasia and ineffective myelopoiesis was noted on bone-marrow histopathology from multiple sites. The absence of other causes suggested a paraneoplastic thrombocytosis. The diagnosis of paraneoplastic thrombocytosis-induced thromboembolism was made due to the lack of underlying cardiac disease and the presence of a marked thrombocytosis. The presence of thrombocytosis and thromboembolism associated with neoplasia is discussed.
D F Hogan; R S Dhaliwal; D D Sisson; B E Kitchell
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Animal Hospital Association     Volume:  35     ISSN:  0587-2871     ISO Abbreviation:  J Am Anim Hosp Assoc     Publication Date:    1999 Nov-Dec
Date Detail:
Created Date:  1999-12-30     Completed Date:  1999-12-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0415027     Medline TA:  J Am Anim Hosp Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  483-6     Citation Subset:  IM    
Department of Veterinary Clinical Medicine, University of Illinois, Urbana 61802, USA.
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MeSH Terms
Aorta, Thoracic / radiography
Bone Marrow / pathology
Cat Diseases / diagnosis*,  etiology,  radiography
Diagnosis, Differential
Euthanasia / veterinary
Fatal Outcome
Lung / pathology
Lung Neoplasms / complications,  diagnosis,  veterinary*
Paraneoplastic Syndromes / complications,  diagnosis,  veterinary*
Thrombocytosis / complications,  diagnosis,  veterinary*
Thromboembolism / etiology,  radiography,  veterinary*

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